Lactic Acid

(rINN)
Lactic Acid Chemical formula

💊 Chemical information

Acide lactique; Acidum lacticum; E270; E326 (potassium lactate); Kwas mlekowy; Kyselina mléčná; Láctico, ácido; Laktik Asit; Maitohappo; Milchsäure; Mjölksyra; Pieno ru _ gštis; Tejsav. 2-Hydroxypropionic acid; 2-Hydroxypropanoic acid.
Chemical formula: C3H6O3 = 90.08.
CAS — 50-21-5; 79-33-4 ((+)-lactic acid); 10326-41-7 (( )-lactic acid); 598-82-3 (( )-lactic acid).
ATC — G01AD01.
ATC Vet — QG01AD01; QP53AG02.

Pharmacopoeias.

In Chin., Int., Jpn, and US. Eur. includes monographs for the racemate and the (S)-enantiomer.

Ph. Eur. 6.2 (Lactic Acid). A mixture of lactic acid, its condensation products, such as lactoyl-lactic acid and other polylactic acids, and water. The equilibrium between lactic acid and polylactic acids depends on the concentration and temperature. It is usually the racemate (RS-lactic acid), and contains the equivalent of 88 to 92% w/w of C 3 H 6 O 3 . A colourless or slightly yellow, syrupy liquid. Miscible with water and with alcohol.

Ph. Eur. 6.2 ((S)-Lactic Acid). A mixture of (S)-lactic acid, its condensation products, such as lactoyl-lactic acid and other polylactic acids, and water. The equilibrium between lactic acid and polylactic acids depends on the concentration and temperature. It contains the equivalent of 88 to 92% w/w of C 3 H 6 O 3 , of which not less than 95% is the (S)-enantiomer. A colourless or slightly yellow, syrupy liquid. Miscible with water and with alcohol.

USP 31

(Lactic Acid). A mixture of lactic acid and lactic acid lactate equivalent to a total of 88 to 92% w/w of C 3 H 6 O 3 . It is obtained by the lactic fermentation of sugars or is prepared synthetically. Lactic acid obtained by fermentation of sugars is laevorotatory, while that prepared synthetically is racemic. A colourless or yellowish, hygroscopic, practically odourless, syrupy liquid. When it is concentrated by boiling, lactic acid lactate is formed. Miscible with water, with alcohol, and with ether; insoluble in chloroform. Store in airtight containers.

💊 Adverse Effects and Treatment

As for Hydrochloric Acid, although in the concentrations used it is less corrosive.

Neonates.

There was evidence that neonates had difficulty in metabolising R-(−)-lactic acid and this isomer and the racemate should not be used in foods for infants less than 3 months old.1
1. FAO/WHO. Toxicological evaluation of certain food additives with a review of general principles and of specifications: seventeenth report of the joint FAO/WHO expert committee on food additives. WHO Tech Rep Ser 539 1974.

💊 Uses and Administration

Lactic acid has actions similar to those of acetic acid and has been used similarly in the treatment of infective skin and vaginal disorders. It has been used in the preparation of lactate injections and infusions to provide a source of bicarbonate for the treatment of metabolic acidosis. It is also applied topically in the treatment of warts, often with salicylic acid, and in emollient creams. Other uses include the treatment of severe aphthous stomatitis in terminally ill, immunocompromised patients. Lactic acid has also been used as a food preservative and as an ingredient of cosmetics.

💊 Preparations

BP 2008: Lactic Acid Pessaries; USP 31: Compound Clioquinol Topical Powder.

Proprietary Preparations

Arg.: Celucrem†; Austria: Espritin; Warzin; Belg.: Lacta-Gynecogel; Braz.: Verrux; Canad.: Dermalac; Lubriderm AHA†; Penederm†; Chile: Eucerin; Fr.: Ictyoderm†; Lactacyd Femina; Ger.: Lactisan; Lactisol; RMS†; Irl.: Relact; Ital.: Saugella Intilac; Unigyn; Malaysia: Avecyde†; Mex.: Acid-Lac; Avecyde; Eucerin Piel con Tendencia Acneica†; Lactibon; NZ: BK†; Philipp.: Lactacyd VG; Pol.: Keratolysin; Port.: Atopic†; Singapore: Avecyde†; Spain: Keratisdin; Swed.: Calmuril; Switz.: Vagoclyss; USA: Lactinol; Lactrex; Venez.: Dermalact; Jabolac†; Lactibon. Multi-ingredient: Arg.: Acilac; Akerat; Callicida; Caminol†; Cellskinlab C + AHA; Coltix†; Controlacne; Dermocridin; Duofilm; Hidrolac; Keracnyl; Lacticare; Muvar; Nutrafilm; Opoenterol†; Oxidermos; Pasem; Ureadin Facial; Verruclean; Verrutopic; Austral.: Aussie Tan Skin Moisturiser; Calmurid; Cornkil†; Dermadrate; Dermatech Wart Treatment; Duofilm; Austria: Calmurid; Calmurid HC; Duofilm; Helo-acid; Hylak; Hylak Forte; Lavagin; Belg.: Aporil; Calmurid†; Braz.: Calope†; Calotrat†; Colpolase; Dermacyd; Dermafree; Duofilm; Kalostop†; Lacticare; Lacto Vagin†; Salic; Canad.: Duofilm; Duoplant; Epi-Lyt; P & S; Penederm†; Viron Wart Lotion; Chile: Akerat; Cuidado Intimo; Duofilm; Eucerin Piel Grasa; Lactacyd; Lacticare†; Node DS; Primacy C+AHA†; Ureadin 30; Cz.: Acne Lotio†; Duofilm; Denm.: Verucid; Fin.: Calmuril; Wicnelact; Fr.: Akerat; Cleanance K; Contragel Vert; Correcteur Anti-Taches; Duofilm; Geliofil; Keracnyl; Kerafilm; Lactacyd Derma; Lactacyd Femina; Lacticare; Pedi-Relax Anti-callosites†; Propy-Lacticare; Saugella; Sebium AKN; Topic 10; Verrufilm; Verrupan; Ger.: Akaderm N; Calmurid†; Clabin; Collomack†; Duofilm; Gehwol Huhneraugen Pflaster†; Sagrosept†; Solco-Derman; Vagisan; W-Tropfen; Warzen-Alldahin†; Gr.: Duofilm; Hong Kong: Collomack; Dermadrate; Dermatech Wart Treatment; Duofilm; Eubos Feminin; Lactacyd; Lacticare†; Solcoderm; Verrufilm; Hung.: Duofilm; India: Cotaryl; Lacgel; Indon.: Exfoliac; Lactacyd; Lacticare; Irl.: Calmurid; Calmurid HC; Cuplex; Duofilm; Lacticare; Salactol; Salatac; Israel: Babyzim; Calmurid; Calmurid HC†; Salatac; U-Lactin Foot Cream; U-Lactin Forte; Ital.: Bruciaporri; Decon Lavanda; Duofilm; Eudermico†; Gastro-Pepsin; Geliofil; Geroderm Zolfo†; Ginil; Ipso Urea; Kerafilmver; Lactacyd Derma; Lactacyd Intimo; Lactocol; Saugella Salviettine; Sensigel; Sensiquell; Triacid; Unidermo; Verel; Verunec; Malaysia: Collomack†; Duofilm; Lactacyd; Lacticare; Lorasil Feminine Hygeine†; Solcoderm†; Mex.: Duofilm; Kinor; Lacticare; Rug-Derm; Urader Lactato; Neth.: Calmurid; Calmurid HC; Duofilm; Norw.: Verucid; NZ: Calmurid†; Dermadrate; Duofilm; Philipp.: Duofilm; Intima; Lactacyd; Lacticare; Pol.: ABE-Plyn; Acerin; Brodacid; Duofilm; Masc na Odciski; Port.: Atopic†; Bioclin Sebo Care; Calicida Indiano; Calmurid; Creme Laser Hidrante; Despigmentante; Duofilm†; Halitol†; Lactacyd†; Lecia†; Pansebase; Pansebase Composto; Secpel; Secpel Composto; Ureadin Maos; Verrucare; Rus.: Solcoderm (Солкодерм); S.Afr.: Duofilm; Kroko; Lacticare; Singapore: Collomack†; Dermadrate; Dermatech Wart Treatment; Duofilm; Lactacyd; Lacticare; U-Lactin; Spain: Antiverrugas; Callicida Cor Pik; Callix; Euzymina Lisina I; Ginejuvent; Keranin; Roidhemo†; Unguento Callicida Naion; Verufil; Switz.: Calmurid; Calmurid HC†; Clabin; Coruzol†; Duofilm; Solcoderm; Va-t’en; Vin Tonique de Vial†; Waruzol; Warz-ab Extor; Thai.: Collomack†; Duofilm; Lactacyd; Lacticare; Turk.: Duoderm; UK: Bazuka; Calmurid; Calmurid HC; Cuplex; Duofilm; Lacticare†; Salactol; Salatac; USA: AmLactin AP; Epi-Lyt; Lacticare; Lactinol-E; SLT†; Venez.: Akerat; Collomack; Duofilm†; Kayivis.
Published May 08, 2019.