Isometheptene Mucate

(BANM, rINNM)
Synonyms: Isométheptène, Mucate d’; Isomethepteni Mucas; Mucato de isometepteno. Isometheptene galactarate.
Cyrillic synonym: Изометептена Мукат.

💊 Chemical information

Chemical formula: (C9H19N)2,C6H10O8 = 492.6.
CAS — 7492-31-1.
ATC — A03AX10.
ATC Vet — QA03AX10.

Pharmacopoeias.

In Br. and US.

BP 2008

(Isometheptene Mucate). A white crystalline powder. Very soluble in water; slightly soluble in dehydrated alcohol; very slightly soluble in chloroform; practically insoluble in ether. A 5% solution in water has a pH of 5.4 to 6.6. Store in airtight containers. Protect from light.

USP 31

(Isometheptene Mucate). A white crystalline powder. Freely soluble in water; soluble in alcohol; practically insoluble in chloroform and in ether. pH of a 5% solution in water is between 6.0 and 7.5.

💊 Adverse Effects and Precautions

As for Sympathomimetics.

Porphyria.

Isometheptene mucate has been associated with acute attacks of porphyria and is considered unsafe in porphyric patients.

💊 Interactions

As for Sympathomimetics. Isometheptene has been reported to produce severe hypertensive reactions in patients receiving MAOIs.

Bromocriptine.

For a report of hypertension and life-threatening complications after use of isometheptene and bromocriptine, see under Sympathomimetics.

💊 Uses and Administration

Isometheptene is an indirect-acting sympathomimetic. It is included for its vasoconstrictor effect, usually as the mucate, in some analgesic combination products used to treat acute migraine attacks. Typical oral doses of isometheptene mucate in migraine are 130 mg at the beginning of an attack, with 65 mg hourly thereafter as necessary, up to a total maximum dose of 325 mg in a 12-hour period. Isometheptene hydrochloride has also been used in the management of migraine and smooth muscle spasm; it has been given orally, as well as by intramuscular, or occasionally subcutaneous, or slow intravenous, injection. The mucate has also been used in the management of muscle spasms.

💊 Preparations

USP 31: Isometheptene Mucate, Dichloralphenazone, and Acetaminophen Capsules.

Proprietary Preparations

Turk.: Octinum. Multi-ingredient: Braz.: Cefaldina; Doralgina; Doridina; Dorsedin; Migranette; Neomigran†; Neosaldina; Neuralgina; Sedalgina; Sedol; Tensaldin; Hong Kong: Midrid†; UK: Midrid; USA: Duradrin†; Midrin; MigraTen; Migratine†.
Published May 08, 2019.