Inulin

(BAN)

💊 Chemical information

Alant Starch; Inulina.
CAS — 9005-80-5.

Pharmacopoeias.

In Br. and US.

BP 2008

(Inulin). A polysaccharide obtained from the tubers of Dahlia variabilis, Helianthus tuberosus, and other genera of the family Compositae. It is a white, odourless or almost odourless, hygroscopic, amorphous, granular powder. Slightly soluble in cold water, but freely soluble in hot water; slightly soluble in organic solvents.

USP 31

(Inulin). A polysaccharide which, on hydrolysis, yields mainly fructose. A white, friable, chalk-like, amorphous, odourless powder. Soluble in hot water; slightly soluble in cold water and in organic solvents. A 10% solution in water has a pH of 4.5 to 7.0. Store at a temperature of 25°, excursions permitted between 15° and 30°.

💊 Pharmacokinetics

Inulin is rapidly removed from the circulation after intravenous doses but is not metabolised. A trace may be found in the bile and may cross the placenta, but it is mainly eliminated in the urine by glomerular filtration without secretion or reabsorption in the renal tubule.

💊 Uses and Administration

Inulin is used intravenously as a diagnostic agent to measure the glomerular filtration rate. Although an accurate test, it is complex to perform and is generally reserved for research purposes. Crystals of inulin may be deposited on storage of the injection; they should be dissolved by heating for not more than 15 minutes before use and the injection cooled to a suitable temperature before use. Polyfructosan, an inulin analogue of lower average molecular weight, has been used similarly.

💊 Preparations

BP 2008: Inulin Injection; USP 31: Inulin in Sodium Chloride Injection.

Proprietary Preparations

Austria: Inutest; Cz.: Inutest†. Multi-ingredient: Chile: Reduc-Te; Reducform-F; Fr.: Actyfilus; Effadiane relipidantes; Ital.: Enterolactis; Lactolas; Naturalass; Snell’it.
Published May 08, 2019.