Synonyms: Antianemic Factor; Castle’s Intrinsic Factor; Gastric Intrinsic Factor.
Cyrillic synonym: Внутренне Присущий Фактор.
💊 Chemical information
CAS — 9008-12-2.
Intrinsic factor, a glycoprotein secreted by the parietal glands in the stomach, is required for absorption of vitamin B12 in the small intestine. Deficiency in intrinsic factor leads to vitamin B12deficiency disorders and pernicious anaemia. Intrinsic factor is given orally with cyanocobalamin in the Schilling test in the differential diagnosis of pernicious anaemia. It is also included in some oral preparations containing cyanocobalamin, presumably as an aid to absorption.
◊ Difficulty in obtaining intrinsic factor and/or radio-labelled cyanocobalamin for the original Schilling test prompted studies using a recombinant human intrinsic factor in a new vitamin B12absorption test.Initial results with this recombinant form were promising.1
1. Hvas A-M, et al. The effect of recombinant human intrinsic factor on the uptake of vitamin B12 in patients with evident vitamin B12 deficiency. Haematologica 2006; 91: 805–8.
Multi-ingredient: Braz.: Hemofer†; Indon.: Biosanbe; Philipp.: TriHEMIC; USA: Anemagen†; Chromagen; Contrin; Ferotrinsic; Fetrin; Livitrinsic-f; Pronemia Hematinic; TriHEMIC; Trinsicon.
Published May 08, 2019.