Synonyms: Catabolin; Endogenous Pyrogen; Haematopoietin-1; IL-1; Interleucina 1; Leucocyte Endogenous Mediator; Lymphocyte Activating Factor.
Cyrillic synonym: Интерлейкин-1.
Interleukin-1 is one of a number of polypeptides known collectively as interleukins. It is produced in blood and a variety of tissues by mononuclear phagocytes involved in the complex regulation of immune responses. It enhances the immune response and has proinflammatory and pyrogenic properties. There are two distinct forms, interleukin-1 α and interleukin-1β. Interleukin-1 may also be produced by recombinant DNA technology, and human recombinant interleukin-1 β has been used as an adjunct to cancer chemotherapy or radiotherapy for its haematopoietic activity. It has also been investigated for its immunotropic effects in purulent infections of the lung and ear, although it has no intrinsic antibacterial activity. Adverse effects of interleukin-1 include fever, chills, flu-like symptoms, hypotension, and pain, swelling, and erythema at the site of subcutaneous injection. Interleukin-1 is also implicated in the pathogenesis of some diseases, particularly auto-immune and inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.
Published May 08, 2019.