Hydrazine Sulfate

(BAN, rINN)
Hydrazine Sulfate Chemical formula

💊 Chemical information

Hidrazina, sulfato de; Hydrazine Sulphate; Hydrazyny siarczan.
Chemical formula: H6N2O4S = 130.1.
CAS — 302-01-2 (hydrazine); 10034-93-2 (hydrazine sulfate).

💊 Profile

Hydrazine sulfate is employed in various industrial processes. It is used in the preparation of hydrazine hydrate which is applied after a solution of platinic chloride for corneal tattooing. It has been tried, but with little if any benefit, in the management of cancer-related anorexia and cachexia.

Adverse effects and treatment.

References to adverse effects resulting from exposure to hydrazine.1-5 Pyridoxine has been used in the management of hydrazine intoxication.6-8
1. Albert DM, Puliafito CA. Choroidal melanoma: possible exposure to industrial toxins. N Engl J Med 1977; 296: 634–5
2. Durant PJ, Harris RA. Hydrazine and lupus. N Engl J Med 1980; 303: 584–5
3. WHO. Hydrazine. Environmental Health Criteri
68. Geneva: WHO, 1987. Available at: http://www.inchem.org/documents/ ehc/ehc/ehc68.htm (accessed 24/07/08
4. WHO. Hydrazine health and safety guide. IPCS Health and Safety Guid
56. Geneva: WHO, 1991. Available at: http:// www.inchem.org/documents/hsg/hsg/hsg056.htm (accessed 24/07/08
5. Hainer MI, et al. Fatal hepatorenal failure associated with hydrazine sulfate. Ann Intern Med 2000; 133: 877–80
6. Kirklin JK, et al. Treatment of hydrazine-induced coma with pyridoxine. N Engl J Med 1976; 294: 938–9.
7. Harati Y, Niakan E. Hydrazine toxicity, pyridoxine therapy, and peripheral neuropathy. Ann Intern Med 1986; 104: 728–9
8. Nagappan R, Riddell T. Pyridoxine therapy in a patient with severe hydrazine sulfate toxicity. Crit Care Med 2000; 28: 2116–18.

Anorexia and cachexia.

References1-3 to the use of hydrazine sulfate in patients with anorexia or cachexia associated with cancer.
1. Tayek JA, et al. Effect of hydrazine sulphate on whole-body protein breakdown measured by C-lysine metabolism in lung cancer patients. Lancet 1987; ii: 241–4
2. Loprinzi CL, et al. Cancer-associated anorexia and cachexia: implications for drug therapy. Drugs 1992; 43: 499–506
3. Kaegi E. Unconventional therapies for cancer: hydrazine sulfate. Can Med Assoc J 1998; 158: 1327–30.

💊 Preparations

Proprietary Preparations

Rus.: Sehydrin (Сегидрин).
Published May 08, 2019.