Guanidine Hydrochloride

(BAN, rINN)
Guanidine Hydrochloride Chemical formula

Chemical information

Carbamidine Hydrochloride; Guanidina, hidrocloruro de; Guanidyny chlorowodorek; Iminourea Hydrochloride.
Chemical formula: CH5N3,HCl = 95.53.
CAS — 113-00-8 (guanidine); 50-01-1 (guanidine hydrochloride).

Profile

Guanidine hydrochloride enhances the release of acetylcholine from nerve terminals. It has been given by mouth to reverse neuromuscular blockade in patients with botulism, but its efficacy has not been established. Guanidine hydrochloride has also been tried in Eaton-Lambert myasthenic syndrome and other neurological disorders, but its use has been associated with bone-marrow suppression in some patients.
1. Kaplan JE, et al. Botulism, type A, and treatment with guanidine. Ann Neurol 1979; 6: 69–71
2. Critchley EMR, et al. Outbreak of botulism in North West England and Wales. Lancet 1989; ii: 849–53
3. Neal KR, Dunbar EM. Improvement in bulbar weakness with guanoxan in type B botulism. Lancet 1990; 335: 1286–7
4. Oh SJ, et al. Low-dose guanidine and pyridostigmine: relatively safe and effective long-term symptomatic therapy in LambertEaton myasthenic syndrome. Muscle Nerve 1997; 20: 1146–52.
Published May 08, 2019.