💊 Chemical information

E425; Glucomanano; Harina de Konjac; Konjac Flour; Konjac Mannan.

💊 Profile

Glucomannan, a powdered extract from the tubers of Amorphophallus konjac, has been promoted as an anorectic. It has been claimed to reduce the appetite by absorbing liquid in the gastrointestinal tract. It is also used in the treatment of constipation and hyperlipidaemia. Glucomannan has been investigated as a dietary adjunct in the management of diabetes mellitus. There is a risk of intestinal or oesophageal obstruction and faecal impaction, especially if it is swallowed dry. Therefore, it should always be taken with sufficient fluid and should not be taken immediately before going to bed. It should be avoided in patients who have difficulty swallowing.
1. Henry DA, et al. Glucomannan and risk of oesophageal obstruction. BMJ 1986; 292: 591–2
2. Renard E, et al. Noninsulin-dependent diabetes and glucose intolerance: effect of glucomannan fibre on blood glucose and serum insulin. Sem Hop Paris 1991; 67: 153–7
3. Vuksan V, et al. Beneficial effects of viscous dietary fiber from konjac-mannan in subjects with the insulin resistance syndrome: results of a controlled metabolic trial. Diabetes Care 2000; 23: 9–14
4. Staiano A, et al. Effect of the dietary fiber glucomannan on chronic constipation in neurologically impaired children. J Pediatr 2000; 136: 41–5
5. Loening-Baucke V, et al. Fiber (glucomannan) is beneficial in the treatment of childhood constipation. Abstract: Pediatrics 2004; 113: 259. Full version: full/113/3/e259 (accessed 23/05/06
6. Keithley J, Swanson B. Glucomannan and obesity: a critical review. Altern Ther Health Med 2005; 11: 30–4
7. Vanderbeek PB, et al. Esophageal obstruction from a hygroscopic pharmacobezoar containing glucomannan. Clin Toxicol 2007; 45: 80–2.

💊 Preparations

Proprietary Preparations

Arg.: Modekal†; Chile: Redicres Rapido†; Fr.: Muraligne†; Ger.: bioNorm mit Konjak†; India: Dietmann; Ital.: Dicoplus; Dietoman; NormaLine; Mex.: Dietoman; Esbeltex; Naturalfit†; Port.: Bioregime†; Florilax†. Multi-ingredient: Arg.: KLB6 Fruit Diet; Chile: Delgadol Fibra; Fr.: Filigel; Ital.: Agioslim; Ecamannan; Glucoman; Lactomannan; Port.: Bioregime Fort†; Bioregime SlimKit†; Excess†.
Published May 08, 2019.