Ginkgolides

(BAN, USAN, rINN)
Ginkgolides Chemical formula
Synonyms: Ginkgólidos.
Cyrillic synonym: Гинкголиды.

💊 Chemical information

Description.

Ginkgolides A, B, and C (BN-52020, BN-52021, and BN-52022 respectively) are isolated from Ginkgo biloba (Ginkgoaceae) (see above).

💊 Profile

Ginkgolides are terpenoid molecules isolated from Ginkgo biloba (above), with platelet-activating factor (PAF) antagonist properties. They have been investigated as BN-52063, a mixture of ginkgolides A (BN-52020), B (BN-52021), and C (BN52022), for asthma and other inflammatory and allergic disorders, and also in immune disorders such as endotoxic shock and graft rejection; ginkgolide B, which has the most potent PAF antagonist properties, has been tried alone in similar conditions. Other ginkgolides, including ginkgolide M (BN-52023) and ginkgolide J (BN-52024), have also been identified.
1. Braquet P. The ginkgolides: potent platelet-activating factor antagonists isolated from Ginkgo biloba L: chemistry, pharmacology and clinical applications. Drugs Of The Future 1987; 12: 643–99
2. Chung KF, et al. Effect of a ginkgolide mixture (BN 52063) in antagonising skin and platelet responses to platelet activating factor in man. Lancet 1987; i: 248–51.
3. Roberts NM, et al. Effect of a PAF antagonist, BN52063, on PAF-induced bronchoconstriction in normal subjects. Br J Clin Pharmacol 1988; 26: 65–72
4. Kleijnen J, Knipschild P. Ginkgo biloba. Lancet 1992; 340: 1136–9
5. Houghton P. Ginkgo. Pharm J 1994; 253: 122–3
6. Brochet B, et al. The Ginkgolide Study Group in Multiple Sclerosis. Double blind placebo controlled multicentre study of ginkgolide B in treatment of acute exacerbations of multiple sclerosis. J Neurol Neurosurg Psychiatry 1995; 58: 360–2
7. Maclennan KM, et al. The CNS effects of Ginkgo biloba extracts and ginkgolide B. Prog Neurobiol 2002; 67: 235–57.

💊 Preparations

Proprietary Preparations

Turk.: Bilokan; Seremaks; Tebokan.
Published May 08, 2019.