Gavestinel

(BAN, USAN, rINN)
Gavestinel Chemical formula
Synonyms: Gavestinelum; GV-150526X. 4,6-Dichloro-3-[(E)-2-(phenylcarbamoyl)vinyl]indole-2-carboxylic acid.
Cyrillic synonym: Гавестинел.

Chemical information

Chemical formula: C18H12Cl2N2O3 = 375.2.
CAS — 153436-22-7.

Profile

Gavestinel is a glycine antagonist that has been investigated as a neuroprotectant in stroke.

Stroke.

Gavestinel has been tried for its supposed neuroprotective properties in acute stroke, but two major multicentre, randomised controlled studies have failed to show any benefit over placebo in acute ischaemic stroke.1,2 Analysis of the data from these two studies in patients with primary intracerebral haemorrhage found no benefit of gavestinel in this subgroup either.3
1. Lees KR, et al. Glycine antagonist (gavestinel) in neuroprotection (GAIN International) in patients with acute stroke: a randomised controlled trial. Lancet 2000; 355: 1949–54
2. Sacco RL, et al. Glycine antagonist in neuroprotection for patients with acute stroke: GAIN Americas: a randomized controlled trial. JAMA 2001; 285: 1719–28
3. Haley EC, et al. Gavestinel does not improve outcome after acute intracerebral hemorrhage: an analysis from the GAIN International and GAIN Americas studies. Stroke 2005; 36: 1006–10.
Published May 08, 2019.