Gabexate Mesilate

(rINNM)
Gabexate Mesilate Chemical formula
Synonyms: Gabexate, Mésilate de; Gabexate Mesylate; Gabexati Mesilas; Mesilato de gabexato. Ethyl 4-(6-guanidinohexanoyloxy)benzoate methanesulphonate.
Cyrillic synonym: Габексата Мезилат.

💊 Chemical information

Chemical formula: C16H23N3O4,CH4SO3 = 417.5.
CAS — 39492-01-8 (gabexate); 56974-61-9 (gabexate mesilate).

Pharmacopoeias.

In Jpn.

💊 Profile

Gabexate mesilate is a proteolytic enzyme inhibitor that has been used for the treatment of pancreatitis in an initial dose of 100 to 300 mg daily given by intravenous infusion. The dose may be reduced, or a further 100 to 300 mg given on the same day, according to response. It has also been used for disseminated intravascular coagulation in a dose of 20 to 39 mg/kg given as a continuous intravenous infusion over 24 hours. Hypersensitivity reactions including anaphylaxis have occurred.
1. Messori A, et al. Effectiveness of gabexate mesilate in acute pancreatitis: a metaanalysis. Dig Dis Sci 1995; 40: 734–8
2. Cavallini G, et al. Gabexate for the prevention of pancreatic damage related to endoscopic retrograde cholangiopancreatography. N Engl J Med 1996; 335: 919–23
3. Matsukawa Y, et al. Anaphylaxis induced by gabexate mesylate. BMJ 1998; 317: 1563
4. Ranucci M, et al. Gabexate mesilate and antithrombin III for intraoperative anticoagulation in heparin pretreated patients. Perfusion 1999; 14: 357–62
5. Matsukawa Y, et al. Fatal cases of gabexate mesilate-induced anaphylaxis. Int J Clin Pharmacol Res 2002; 22: 81–3
6. Masci E, et al. Comparison of two dosing regimens of gabexate in the prophylaxis of post-ERCP pancreatitis. Am J Gastroenterol 2003; 98: 2182–6
7. Andriulli A, et al. Prophylaxis of ERCP-related pancreatitis: a randomized, controlled trial of somatostatin and gabexate mesylate. Clin Gastroenterol Hepatol 2004; 2: 713–18
8. Hsu JT, et al. Efficacy of gabexate mesilate on disseminated intravascular coagulation as a complication of infection developing after abdominal surgery. J Formos Med Assoc 2004; 103: 678–84
9. Rudin D, et al. Somatostatin and gabexate for post-endoscopic retrograde cholangiopancreatography pancreatitis prevention: meta-analysis of randomized placebo-controlled trials. J Gastroenterol Hepatol 2007; 22: 977–83.

💊 Preparations

Proprietary Preparations

Ital.: Foy; Jpn: Foy.
Published May 08, 2019.