Fucoidan

(USAN, rINNM)
Synonyms: Fucoidin; Fucoidine; Nemacystus Mucilage.
Cyrillic synonym: Фукоидан.

💊 Chemical information

CAS — 9072-19-9.

💊 Profile

Fucoidan is a sulfated polysaccharide, based mainly on L-fucose, that is extracted from brown seaweed. It is reported to have anticoagulant, antithrombotic, and antineoplastic activity and has been promoted for a wide-range of disorders and as a food supplement.
1. Mourão PA. Use of sulfated fucans as anticoagulant and antithrombotic agents: future perspectives. Curr Pharm Des 2004; 10: 967–81.

Nomenclature.

Fucans are a class of sulfated polysaccharides first isolated from marine algae. Their nomenclature can be somewhat varied and confusing. The original polysaccharide isolated from algae was termed fucoidin and this was later changed to fucoidan. These polysaccharides have also been found in marine invertebrates and improved analytical and separation techniques have allowed different types of sulfated polysaccharides to be identified. It has been suggested that the term sulfated fucan should be defined as a polysaccharide based mainly on sulfated L-fucoses, with less than 10% other monosaccharides.1 This term has been applied to the sulfated fucans of marine invertebrates, whereas the term fucoidan has been used for fucans extracted from algae. Some define fucoidan as a sulfated polysaccharide of L-fucose and D-galactose extracted from brown seaweed although others have used this term for sulfated polysaccharide complexes having a content of L-fucose of only 60% or less. Other terms that have been coined for these compounds include fucansulfate and fucan sulfate.
1. Berteau O, Mulloy B. Sulfated fucans, fresh perspectives: structures, functions, and biological properties of sulfated fucans and an overview of enzymes active toward this class of polysaccharide. Glycobiology 2003; 13: 29R–40R.

💊 Preparations

Proprietary Preparations

Indon.: Mozuku.
Published May 08, 2019.