Synonyms: Fingolimodum; FTY-720 (fingolimod hydrochloride). 2-Amino-2[2-(4-octylphenyl)ethyl]propane-1,3-diol.
Cyrillic synonym: Финголимод.
Chemical formula: C19H33NO2 = 307.5.
CAS — 162359-55-9 (fingolimod); 162359-56-0 (fingolimod hydrochloride).
NOTE. Fingolimod hydrochloride is USAN.
Fingolimod is an immunomodulator under investigation for multiple sclerosis and prophylaxis of acute rejection in kidney transplantation. Fingolimod is a prodrug, which after phosphorylation, acts as a sphingosine-1-phosphate receptor agonist that binds to the surface of lymphocytes and redirects them from the bloodstream and graft sites to the lymph nodes.
1. Kappos L, et al. Oral fingolimod (FTY720) for relapsing multiple sclerosis. N Engl J Med 2006; 355: 1124–40.
Published May 08, 2019.