Fenoverine

(rINN)
Fenoverine Chemical formula
Synonyms: Fenoverina; Fénovérine; Fenoverinum. 10-[(4-Piperonyl-1-piperazinyl)acetyl]phenothiazine.
Cyrillic synonym: Феноверин.

💊 Chemical information

Chemical formula: C26H25N3O3S = 459.6.
CAS — 37561-27-6.
ATC — A03AX05.
ATC Vet — QA03AX05.

💊 Profile

Fenoverine has been used as an antispasmodic but has been withdrawn in some countries after reports of rhabdomyolysis.

Adverse effects.

Reports of rhabdomyolysis associated with fenoverine,1-3 including a fatality.1 A genetic predisposition has been suggested.2
1. Chariot P, et al. Fenoverine-induced rhabdomyolysis. Hum Exp Toxic ol 1995; 14: 654–6
2. Jouglard J, et al. Research into individual predisposition to develop acute rhabdomyolysis attributed to fenoverine. Hum Exp Toxic ol 1996; 15: 815–20
3. Chen CW, Chang MH. Rhabdomyolysis induced by fenoverine: a case report and literature review. Acta Neurol Taiwan 2005; 14: 143–6.

💊 Preparations

Proprietary Preparations

Mex.: Spasmopriv; Singapore: Spasmopriv; Thai.: Spasmopriv; Tavidan†.
Published May 08, 2019.