Eniluracil

(BAN, USAN, rINN)
Eniluracil Chemical formula
Synonyms: 776C85; Eniluracilo; Eniluracilum. 5-Ethynyluracil.
Cyrillic synonym: Энилурацил.

Chemical information

Chemical formula: C6H4N2O2 = 136.1.
CAS — 59989-18-3.

Profile

Eniluracil inactivates the enzyme dihydropyrimidine dehydrogenase, which plays an important role in the metabolism of the antineoplastic fluorouracil. Eniluracil increases the bioavailability of fluorouracil, particularly when the latter is given by mouth. It is being investigated as an adjunct to fluorouracil therapy in the treatment of colorectal, breast, and pancreatic cancer. However, the optimal dose and regimen remains to be determined.
Published May 08, 2019.