Edodekin Alfa

(USAN, rINN)
Synonyms: Edodekina alfa; Édodékine Alfa; Edodekinum Alfa; Ro-247472/000.
Cyrillic synonym: Эдодекин Альфа.

Chemical information

CAS — 187348-17-0.

Description.

A recombinant human interleukin-12.

Profile

Interleukin-12 is one of a number of polypeptides known collectively as interleukins. It is produced by macrophages and dendritic cells and enhances cellular immunity through induction of the activity of interferonγ and cytotoxic T-lymphocytes. It has been investigated for the treatment of severe infections such as mycobacterial infections; it is worthy of note that children with a rare inherited susceptibility to fatal mycobacterial infections exhibit mutations in the interleukin-12 gene. Interleukin-12 is also under study for the treatment of various cancers, including as adenovirus-mediated gene therapy. Edodekin alfa is human recombinant interleukin-12 under investigation for the treatment of renal cell carcinoma.
1. Mazzolini G, et al. Gene therapy of cancer with interleukin-12. Curr Pharm Des 2003; 9: 1981–91
2. Kikuchi T, et al. Vaccination of glioma patients with fusions of dendritic and glioma cells and recombinant human interleuki
12. J Immunother 2004; 27: 452–9
3. Trudeau C, et al. A single administration of recombinant human interleukin-12 is associated with increased expression levels of interferon-gamma and signal transducer and activator of transcription in healthy subjects. J Clin Pharmacol 2005; 45: 649–58
4. Sangro B, et al. Gene therapy of cancer based on interleuki
12. Curr Gene Ther 2005; 5: 573–81
5. Little RF, et al. Activity of subcutaneous interleukin-12 in AIDS-related Kaposi sarcoma. Blood 2006; 107: 4650–7.
Published May 08, 2019.