Ebselen
(rINN)
Synonyms: DR-3305; Ebsélène; Ebseleno; Ebselenum; PZ-51. 2-Phenyl-1,2benzisoselenazolin-3-one.
Cyrillic synonym: Эбселен.
Chemical information
Chemical formula: C13H9NOSe = 274.2.
CAS — 60940-34-3.
Profile
Ebselen has antoxidant activity and inhibits lipid peroxidation. It has been investigated as a neuroprotectant in stroke.
◊ References.
1. Yamaguchi T, et al. Ebselen in acute ischemic stroke: a placebocontrolled, double-blind clinical trial. Stroke 1998; 29: 12–17
2. Saito I, et al. Neuroprotective effect of an antioxidant, ebselen, in patients with delayed neurological deficits after aneurysmal subarachnoid hemorrhage. Neurosurgery 1998; 42: 269–78.
2. Saito I, et al. Neuroprotective effect of an antioxidant, ebselen, in patients with delayed neurological deficits after aneurysmal subarachnoid hemorrhage. Neurosurgery 1998; 42: 269–78.
Published May 08, 2019.