Drotaverine

(rINN)
Drotaverine Chemical formula
Synonyms: Drotaverina; Drotavérine; Drotaverinum. 1-(3,4-Diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline.
Cyrillic synonym: Дротаверин.

💊 Chemical information

Chemical formula: C24H31NO4 = 397.5.
CAS — 14009-24-6 (drotaverine); 985-12-6 (drotaverine hydrochloride).
ATC — A0 3AD02.
ATC Vet — QA03AD02.

Pharmacopoeias.

Pol. includes Drotaverine Hydrochloride.

💊 Profile

Drotaverine is used as an antispasmodic in the management of biliary-tract, urinary-tract, and gastrointestinal spasm, in usual oral doses of 120 to 240 mg daily in divided doses. It has also been given by intramuscular or intravenous injection.
1. Bolaji OO, et al. Pharmacokinetics and bioavailability of drotaverine in humans. Eur J Drug Metab Pharmacokinet 1996; 21: 217–21
2. Romics I, et al. The effect of drotaverine hydrochloride in acute colicky pain caused by renal and ureteric stones. BJU Int 2003; 92: 92–6
3. Singh KC, et al. Drotaverine hydrochloride for augmentation of labor. Int J Gynaecol Obstet 2004; 84: 17–22.

Porphyria.

Drotaverine has been associated with acute attacks of porphyria and is considered unsafe in porphyric patients.

💊 Preparations

Proprietary Preparations

Arg.: Proconfial†; Cz.: No-Spa; Hung.: No-Spa; India: Drotin; Drovera†; DVN; Malaysia: No-Spa; Philipp.: No-Spa; Pol.: Galospa; No-Spa; Rus.: Bezpa (Беспа); No-Spa (Но-Шпа); Spacovin (Спаковин); Spasmol (Спазмол); Spazoverin (Спазоверин); Thai.: D-Tarine†; Deolin; No-Spa; Spablock; Spacovin; Sparax; Sparta; Toverine. Multi-ingredient: Cz.: Quarelin†; Hung.: Algoflex-M; Algopyrin Complex; No-Spalgin; Paniverin; Quarelin; Rus.: No-Spalgin (Но-Шпалгин).
Published May 08, 2019.