Dipivefrine Hydrochloride

(BANM, rINNM)
Synonyms: Dipivalyl Adrenaline Hydrochloride; Dipivalyl Epinephrine Hydrochloride; Dipivefriinihydrokloridi; Dipivefrin Hydrochloride; Dipivéfrine, chlorhydrate de; Dipivefrin-hydrochlorid; Dipivefrinhydroklorid; Dipivefrini hydrochloridum; Dipivefrino hidrochloridas; Dipiwefryny chlorowodorek; Hidrocloruro de dipivefrina. (RS)-4-[1-Hydroxy-2-(methylamino)ethyl]o-phenylene dipivalate hydrochloride.
Cyrillic synonym: Дипивефрина Гидрохлорид.

💊 Chemical information

Chemical formula: C19H29NO5,HCl = 387.9.
CAS — 64019-93-8.
ATC — S01EA02.
ATC Vet — QS01EA02.

Pharmacopoeias.

In Chin., Eur., and US.

Ph. Eur. 6.2

(Dipivefrine Hydrochloride). A white or almost white crystalline powder. Freely soluble in water, in alcohol, and in dichloromethane; very soluble in methyl alcohol.

USP 31

(Dipivefrin Hydrochloride). White, crystalline powder or small crystals, having a faint odour. Very soluble in water. Store in airtight containers.

💊 Profile

Dipivefrine is an ester and prodrug of adrenaline. A 0.1% solution of the hydrochloride is used topically as eye drops to reduce intra-ocular pressure in patients with open-angle glaucoma or ocular hypertension.
1. Parrow KA, et al. Is it worthwhile to add dipivefrin HCl 0.1% to topical β -, β -blocker therapy? Ophthalmology 1989; 96: 1338–41.
2. Drake MV, et al. Levobunolol compared to dipivefrin in African American patients with open angle glaucoma. J Ocul Pharmacol 1993; 9: 91–5. Correction. ibid.; 385
3. Albracht DC, et al. A double-masked comparison of betaxolol and dipivefrin for the treatment of increased intraocular pressure. Am J Ophthalmol 1993; 116: 307–13
4. Widengard I, et al. Effects of latanoprost and dipivefrin, alone or combined, on intraocular pressure and on blood-aqueous barrier permeability. Br J Ophthalmol 1998; 82: 404–6.

💊 Preparations

BP 2008: Dipivefrine Eye Drops; USP 31: Dipivefrin Hydrochloride Ophthalmic Solution.

Proprietary Preparations

Arg.: Propine†; Austral.: Dipoquin; Propine; Austria: Glaucothil†; Belg.: Propine; Braz.: Propine; Canad.: Propine†; Cz.: d Epifrin†; Oftanex†; Denm.: Oftapinex†; Propine; Fin.: Oftapinex†; Propine; Fr.: Propine; Ger.: d Epifrin; Glaucothil; Gr.: Diopine†; Glaucodose; Prodren†; Thilodrin; Hong Kong: Propine; Irl.: Propine; Israel: Difrin; Ital.: Propine; Jpn: Pivalephrine; Malaysia: Propine†; Mex.: Diopine†; Neth.: Diopine; Norw.: Oftapinex†; Propine; NZ: Dipoquin†; Propine; Port.: Propine†; S.Afr.: Propine†; Singapore: Propine†; Spain: Diopine; Glaudrops†; Swed.: Oftapinex†; Propine; Switz.: Diopine†; Thai.: Propine†; UK: Propine; USA: AkPro; Propine. Multi-ingredient: Austria: Thiloadren; Thilodigon†; Canad.: Probeta†; Ger.: Thiloadren N; Thilodigon; Gr.: Ryvina†; Thilocombin†.
Published May 08, 2019.