Dimethyl Sulfone
(rINN)
💊 Chemical information
Chemical formula: Dimethyl Sulphone; Dimetylosulfon; DMSO2; Methyl Sulphone; Methylsulfonylmethane; Methylsulphonylmethane; MSM; Sulfonylbismethane.
Chemical formula: C2H6O2S = 94.13.
CAS — 67-71-0.
Tolinol; p-Tolylmethylcarbinol; Tolynolum. 1-(p-Tolyl)ethanol.
Chemical formula: C9H12O = 136.2.
CAS — 536-50-5.
NOTE. The name tolynol has been applied to both p,α-dimethylbenzyl alcohol and mephenesin.
💊 Profile
Dimethyl sulfone is an oxidation product of dimethyl sulfoxide and has been used similarly as an organic solvent. It may be responsible for some of the pharmacological actions of dimethyl sulfoxide and has been tried in disorders including osteoarthritis, allergic rhinitis, and interstitial cystitis. It has also been used as a nutritional supplement.
◊ References.
1. Ely A, Lockwood B. What is the evidence for the safety and efficacy of dimethyl sulfoxide and methylsulfonylmethane in pain relief? Pharm J 2002; 269: 685–7
2. Anonymous. Methylsulfonylmethane (MSM). Altern Med Rev 2003; 8: 438–41
3. Brien S, et al. Systematic review of the nutritional supplements dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in the treatment of osteoarthritis. Osteoarthritis Cartilage 2008. Available at: doi: 10.1016/j.joca.2008.03.002
2. Anonymous. Methylsulfonylmethane (MSM). Altern Med Rev 2003; 8: 438–41
3. Brien S, et al. Systematic review of the nutritional supplements dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in the treatment of osteoarthritis. Osteoarthritis Cartilage 2008. Available at: doi: 10.1016/j.joca.2008.03.002
💊 Preparations
USP 31: Glucosamine and Methylsulfonylmethane Tablets; Glucosamine, Chondroitin Sulfate Sodium, and Methylsulfonylmethane Tablets; Methylsulfonylmethane Tablets. Proprietary PreparationsMulti-ingredient: Canad.: Glucosamine Joint & Muscle Cream with MSM†; Indon.: Aptivium Optimum Joint Formula; Artriox; Artritin; Maxitrin; Naturica Artro Plus; OA Plus; Osteoflam; Osteokom; Osteokom Forte; Osteor Plus; Osvion Plus; Triflexor; Triostee; Viopor-M; Ital.: Neosulfur; Osteoclar; Reumafort; S.Afr.: ProFLEX 750; UK: GlucOsamax; NatraFlex; PainEaze. p,α-Dimethylbenzyl Alcohol Tolinol; p-Tolylmethylcarbinol; Tolynolum. 1-(p-Tolyl)ethanol. C 9 H 12 O = 136.2. CAS — 536-50-5. NOTE. The name tolynol has been applied to both p,α-dimethylbenzyl alcohol and mephenesin.
💊 Profile
p,α-Dimethylbenzyl alcohol has been used as a choleretic in the treatment of hepatic disorders and is an ingredient of preparations for gastrointestinal disorders. p, α-Dimethylbenzyl alcohol nicotinate has also been used.
💊 Preparations
Proprietary Preparations
Multi-ingredient: Austria: Apozema; Galle-Donau; Spagall; Spasmo Claim.
Published May 08, 2019.