Dextrorphan Hydrochloride

Synonyms: Dextrorphane, Chlorhydrate de; Dextrorphani Hydrochloridum; Hidrocloruro de dextrorfano; Ro-01-6794/706.
Cyrillic synonym: Декстрорфана Гидрохлорид.

Chemical information

Chemical formula: C17H23NO,HCl = 293.8.
CAS — 69376-27-8.


Dextrorphan, a metabolite of dextromethorphan, is an antagonist of the excitatory neurotransmitter N-methylD-aspartate (NMDA). It possesses some cough suppressant activity and has been investigated as a neuroprotective agent in the management of stroke.
1. Albers GW, et al. Safety, tolerability, and pharmacokinetics of the N-methyl-D-aspartate antagonist dextrorphan in patients with acute stroke. Stroke 1995; 26: 254–8.
Published May 08, 2019.