Dextran Sulfate

(BANM, rINNM)
Synonyms: Dextran, Sulfate de; Dextran Sulfate Sodium; Dextran Sulphate; Dextran Sulphate Sodium; Dextrani Sulfas; Sulfato de dextran.
Cyrillic synonym: Декстрана Сульфат.

💊 Chemical information

CAS — 9011-18-1.
ATC — B05AA05.
ATC Vet — QB05AA05.

Pharmacopoeias.

In Jpn.

💊 Profile

Dextran sulfate is the sodium salt of sulfuric acid esters of dextran. It has been used as an anticoagulant and as a lipid regulating drug, and has been investigated for its antiviral activity. Dextran sulfate potassium has also been used.

Interactions.

1,2 Withdrawal of the ACE inhibitor for 1 to 3 days before apheresis may prevent the reaction.2
1. Olbricht CJ, et al. Anaphylactoid reactions, LDL apheresis with dextran sulphate, and ACE inhibitors. Lancet 1992; 340: 908–9
2. Agishi T. Anion-blood contact reaction (ABC reaction) in patients treated by LDL apheresis with dextran sulfate-cellulose column while receiving ACE inhibitors. JAMA 1994; 271: 195–6.

💊 Preparations

Proprietary Preparations

Multi-ingredient: Arg.: Diroseal; Austral.: VR†; Chile: Cicapost; Diroseal; Ureadin Rx DB; Cz.: Doxivenil†; Fr.: Avene Antirougeurs; Creme au Melilot Composee; Dextrarine Phenylbutazone; Diroseal; Prebutix; Ger.: Phlebodril N; Hung.: Doxivenil; Ital.: Stranoval; Port.: Cicapost; Doxivenil; Switz.: Doxivenil; Venez.: Doxivenil.
Published May 08, 2019.