Dexpanthenol

(BAN, USAN, rINN)
Synonyms: Dekspantenoli; Dekspantenolis; Dexpantenol; Dexpanthénol; Dexpanthenolum; Dextro-Pantothenyl Alcohol; Pantothenol; Provitamin B 5 . (R)-2,4-DihydroxyN-(3-hydroxypropyl)-3,3dimethylbutyramide.
Cyrillic synonym: Декспантенол.

💊 Chemical information

Chemical formula: C9H19NO4 = 205.3.
CAS — 81-13-0.
ATC — A11HA30; D03AX03; S01XA12.
ATC Vet — QA11HA30; QD03AX03; QS01XA12.

Pharmacopoeias.

In Eur., US, and Viet.

Ph. Eur. 6.2

(Dexpanthenol). A colourless or slightly yellowish, hygroscopic, viscous liquid, or a white or almost white, crystalline powder. Very soluble in water; freely soluble in alcohol. A 5% solution in water has a pH not greater than 10.5. Store in airtight containers.

USP 31

(Dexpanthenol). A clear, viscous, somewhat hygroscopic liquid, having a slight characteristic odour. Some crystallisation may occur on standing. Freely soluble in water, in alcohol, in methyl alcohol, and in propylene glycol; soluble in chloroform and in ether; slightly soluble in glycerol. Store in airtight containers.

💊 Adverse Effects and Precautions

There have been a few reports of allergic reactions possibly associated with dexpanthenol. Dexpanthenol is contra-indicated in haemophiliacs and in patients with ileus due to mechanical obstruction.

💊 Uses and Administration

Dexpanthenol is the alcoholic analogue of D-pantothenic acid. It has been given intramuscularly in doses of 250 to 500 mg to prevent or control gastrointestinal atony but its value has not been established. It has also been given by slow intravenous infusion. Dexpanthenol and the racemate panthenol have been used topically in strengths of 2 or 5% for the treatment of various minor skin disorders. They are also included in some vitamin preparations.
1. Kehrl W, Sonnemann U. Verbesserung der Wundheilung nach Nasenoperationen durch kombinierte Anwendung von Xylometazolin und Dexpanthenol. Laryngorhinootologie 2000; 79: 151–4
2. Gehring W, Gloor M. Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration: results of a human in vivo study. Arzneimittelforschung 2000; 50: 659–63
3. Ebner F, et al. Topical use of dexpanthenol in skin disorders. Am J Clin Dermatol 2002; 3: 427–33
4. Biro K, et al. Efficacy of dexpanthenol in skin protection against irritation: a double-blind, placebo-controlled study. Contact Dermatitis 2003; 49: 80–4
5. Rockmann H, et al. Anaphylaxis after dexpanthenol exposure by multivitamin tablets. Clin Exp Dermatol 2005; 30: 714–16.

💊 Preparations

USP 31: Dexpanthenol Preparation.

Proprietary Preparations

Arg.: Nutraisdin†; Recugel; Austria: Bepanthen; Corneregel; Pantothen; Braz.: Bepantol; Uvless; Chile: Bepantol; Cz.: Bepanthen; Panthenol; Fin.: Bepanthen; Fr.: Bepanthen; Bepanthene; Pan-Sun; Ger.: Bepanthen; Corneregel; Marolderm; NasenSpray Panthenol; Nasic-cur; Otriven mit Dexpanthenol; Pan Rhinol; Pan-Ophtal; Panthenol; Panthogenat†; Pelina; Rhinoclir†; Siozwo Sana; Ucee D†; Urupan†; Wund- und Heilsalbe N†; Wundund Heilcreme N; Gr.: Corneregel; Hung.: Bepanthen; Corneregel; Panthenol; Indon.: Bepanthen; Pasquam; Israel: Bepanthen; Neocutan; Ital.: Bepanten; Mex.: Bepanthen; Corneregel; NZ: Bepanthen; Philipp.: Corneregel; Pol.: Bepanthen; Corneregel; Dermopanten; Port.: Bepanthene; Rus.: Bepanthen (Бепантен); Corneregel (Корнерегель); Panthenol (Пантенол); Panthoderm (Пантодерм); S.Afr.: Bepanthen; Bepantol†; Singapore: Bepanthen; Spain: Bepanthene; Switz.: Bepanthene; Tur k.: Bepanthene; Bepantol; Pantenol; UAE: Dexipan; UK: Bepanthen; USA: Ilopan; Panthoderm; Venez.: Beducen†. Multi-ingredient: Arg.: Dermocridin; Dermvien†; Heduline; Hydratone†; Lociherp Liposomas Vitaminado; Mucobase; Nutraisdin†; Sebulex; Talowin; Austral.: Macro Natural Vitamin E Cream; Sebirinse; Superfade; Austria: Beneuran Vit B-Komplex†; Bepanthen; Bepanthen Plus; Colda; Coldistan; Dolobene; Keratosis; Keratosis forte; Oleovit; Panto Liquid; Siccaprotect; Sigman-Haustropfen; Venobene; Belg.: Algi-Cool; Purigel NF; Braz.: Capel; Dolobene; Naridrin; Nariflux; Nazobio†; Varizol†; Canad.: Selsun with Provitamin B †; Chile: Acnoxyl Shampoo Cabello Graso†; Cicapost; Eucerin Piel Grasa; Panthoderm-A; Pomada Vitaminica; Queratopil; Ureadin Rx DB; Ureadin Rx RD; Vitis Encias Colutorio; Vitis Encias Pasta; Cz.: Bepanthen Plus; Brand- und Wundgel†; Dolobene; Lipovitan†; Panlid; Siccaprotect; Fin.: Oftan A-Pant; Pantyson; Wicaran; Wicarba; Wicnevit; Fr.: Alkagin; Mela’aura; Parogencyl gencives fragilisees†; Tonimer; Ger.: Bepanthen Antiseptische; Brand- und Wund-Gel Eu Rho†; Dispatenol; Dolobene; Essaven Tri-Complex†; GeloBacin; Hermalind†; Hewekzem novo N; Hydro Cordes; Hylo-Care; Lipo Cordes; Lipovitan†; Mar Plus†; Nasic; PC 30 V; Remederm; Saseem; Siccaprotect; Gr.: Aquasol A†; Novaquasol-A; Hong Kong: Dolobene; Mar Plus; Pregnacare; Sebirinse; Hung.: Alksebor; Aurobin; Bepanthen Plus; Dolobene; Phlogosam; Vipsogal†; India: Optineuron; Sioneuron; Vitneurin; Indon.: Romilar; Skintex; Israel: Bepanthen Plus; Kamil Blue; Neocutan Silver; Panthisone; Pedisol; Ital.: Alfa Acid; Emazian B12†; Emoantitossina†; Gastrotuss; Keto Z; Lenirose†; Parogencyl; Rinopanteina; Malaysia: Mar Plus; Mex.: Bexident Pediatrics†; Cetopic; Emolin Neo; Nutrem; Salilex; Neth.: Prunacolon; Prunasine; NZ: Sebirinse; Philipp.: pHCare; Remederm; Sebo Fluid; Pol.: Acodin; Alantan-Plus; Bepanthen Plus; Dolobene; Port.: Bepanthene; Bepanthene Plus; Bexident; Carmitol; Cicapost; Efluvium Anti-seborreico; Lactigriet; Nutraisdin; Ureadin 10 Plus; Rus.: Aurobin (Ауробин); Bepanthen Plus (Бепантен Плюс); Dolobene (Долобене); Hepatrombin (Гепатромбин); Hylozar-COMOD (Хилозар-КОМОД); Venolife (Венолайф); S.Afr.: Broncol†; Switz.: Alphastria; Bepanthene Plus; Carbamide + VAS; Carbamide Creme; Cortimycine; Demostan N; Dermacalm-d; Dolobene; Galamila; Gorgonium; Hepathrombine†; Leniderm†; Lyman; Nose Fresh au D-panthenol; Osa Gel de dentition; Parapic; Pelsano; Pigmanorm; Remexal; Siccalix; Siccaprotect; Sportium; Sportusal; Sportusal Spray sine heparino; Stilex; Tendro; Turexan Capilla; Turexan Lotion; Unathene; Unatol; Venucreme; Venugel; Wulnasin; Thai.: Mar Plus; Romilar; Turk.: Bepanthene Plus; Pantenol Plus; Siccaprotect; Stilex; UK: Oilatum Scalp Intensive; Uvistat Eye Drops; Vipsogal; Venez.: Cepin; Diadex; Pantonic; Vitenol†.
Published May 08, 2019.