Dehydrocholic Acid

(BAN, rINN)
Synonyms: Acide Déhydrocholique; Ácido dehidrocólico; Acidum Dehydrocholicum; Chologon; Dehydrocholsyra; Dehydrokoolihappo; Triketocholanic Acid. 3,7,12-Trioxo-5
Cyrillic synonym: Дегидрохолевая Кислота.

💊 Chemical information

Chemical formula: C24H34O5 = 402.5.
CAS — 81-23-2 (dehydrocholic acid); 145-41-5 (sodium dehydrocholate).

Pharmacopoeias.

In Chin., It., Jpn, and US.

USP 31

(Dehydrocholic Acid). A white, fluffy, odourless powder. Practically insoluble in water; soluble 1 in 100 of alcohol, 1 in 135 of acetic acid at 15°, 1 in 130 of acetone at 15°, 1 in 35 of chloroform, 1 in 2200 of ether at 15°, 1 in 135 of ethyl acetate at 15°, and 1 in 960 of benzene at 15°; solutions in alcohol and in chloroform are usually slightly turbid; soluble in glacial acetic acid and in solutions of alkali hydroxides and carbonates.

💊 Profile

Dehydrocholic acid is a semisynthetic bile acid that is given for its hydrocholeretic properties, increasing the volume and water content of the bile without appreciably altering the content of bile acids. It has been used to improve biliary drainage and has also been given for the temporary relief of constipation. The usual oral dose is 250 to 500 mg three times daily after meals. Dehydrocholic acid is contra-indicated in significant cholelithiasis, complete mechanical biliary obstruction, and in severe hepatic impairment.

💊 Preparations

USP 31: Dehydrocholic Acid Tablets.

Proprietary Preparations

USA: Cholan-HMB; Decholin. Multi-ingredient: Arg.: Arnol; Bagohepat; Bibol Leloup; Bil 13; Bil 13 Enzimatico; Bilagol; Carbogasol Digestivo; Digenorflat; Hepadigenor†; Hepatalgina; Lorbihepatic; Novodig†; Pakinase; Palatrobil; Pankreon Compuesto†; Pankreon Total; Zimerol; Braz.: B-Vesil; Digeplus; Digestron†; Essen; Filogaster†; Plasil Enzimatico; Sintozima; Hong Kong: Bilsan; Hung.: Neo-Bilagit; Mex.: Bagohepat; Plasil Enzimatico; Philipp.: Spasmo-Canulase; Pol.: Rapacholin C; Rapacholin Forte; Port.: Espasmo Canulase; S.Afr.: Spasmo-Canulase; Spain: Nulacin Fermentos; Switz.: Spasmo-Canulase.
Published May 08, 2019.