Cytisine

(rINN)
Cytisine Chemical formula
Synonyms: Baptitoxine; Laburnine; Sophorine; Ulexine. 1,2,3,4,5,6-Hexahydro-1,5-methano-8H-pyrido[1,2a][1,5]diazocin-8-one.
Cyrillic synonym: Цитизин.

💊 Chemical information

Chemical formula: C11H14N2O = 190.2.
CAS — 485-35-8.

💊 Profile

Cytisine is a highly toxic alkaloid found in laburnum and some other leguminous plants. It resembles nicotine in its actions and has been given orally as an aid to smoking cessation. The dose is 1.5 mg 6 times daily for 3 days which is then gradually reduced over the next 3 weeks to 1.5 to 3 mg daily for the final 5 days of treatment. Treatment of adverse effects of cytisine is as described for Nicotine. A 0.15% solution of cytisine known as Cytitone has been used intravenously or intramuscularly in some countries as a respiratory stimulant.
1. Etter J-F. Cytisine for smoking cessation: a literature review and a meta-analysis. Arch Intern Med 2006; 166: 1553–9
2. Tutka P, Zatoński W. Cytisine for the treatment of nicotine addiction: from a molecule to therapeutic efficacy. Pharmacol Rep 2006; 58: 777–98.

💊 Preparations

Proprietary Preparations

Bulg.: Tabe x ( Табекс); Hung.: Tabex†; Pol.: Tabex; Rus.: Tabex (Табекс).
Published May 08, 2019.