Corbadrine

(rINN)
Synonyms: Corbadrina; Corbadrinum; l-3,4-Dihydroxynorephedrine; Levonordefrin; l-Nordefrin. (−)-2-Amino-1-(3,4-dihydroxyphenyl)propan-1-ol.
Cyrillic synonym: Корбадрин.

💊 Chemical information

Chemical formula: C9H13NO3 = 183.2.

Pharmacopoeias.

In US.

USP 31

(Levonordefrin). A white to buff-coloured, odourless, crystalline solid. Practically insoluble in water; slightly soluble in alcohol, in acetone, in chloroform, and in ether; freely soluble in aqueous solutions of mineral acids.

💊 Profile

Corbadrine is a sympathomimetic that has been added to local anaesthetic preparations in dentistry to diminish absorption and to localise the effect; a concentration of 1 in 20 000 has been used.

💊 Preparations

USP 31: Mepivacaine Hydrochloride and Levonordefrin Injection; Procaine and Tetracaine Hydrochlorides and Levonordefrin Injection; Propoxycaine and Procaine Hydrochlorides and Levonordefrin Injection.

Proprietary Preparations

Used as an adjunct in: Canad.: Polocaine†; USA: Carbocaine with NeoCobefrin; Isocaine; Polocaine.
Published May 08, 2019.