Citric Acid Monohydrate

(rINN)

💊 Chemical information

Ácido del Limón; Acidum citricum monohydricum; Cítrico monohidrato, ácido; Citrinu ru _ gštis monohidratas; Citrique hydrat; Hydrous Citric Acid; Kwas cytrynowy jednowodny; Kyselina citronová monohydrát; Sitruunahappomonohydraatti.
Chemical formula: C6H8O7,H2O = 210.1.
CAS — 5949-29-1.
ATC — A09AB04.
ATC Vet — QA09AB04.

Pharmacopoeias.

In Chin., Eur., Int., Jpn, US, and Viet.

Ph. Eur. 6.2

(Citric Acid Monohydrate). Efflorescent, colourless crystals or granules, or a white or almost white crystalline powder. Very soluble in water; freely soluble in alcohol. Store in airtight containers.

USP 31

(Citric Acid Monohydrate). Colourless, translucent crystals, or a white, granular to fine, crystalline powder. It is efflorescent in dry air. Soluble 1 in 0.5 of water, 1 in 2 of alcohol, and 1 in 30 of ether. Store in airtight containers.

💊 Adverse Effects and Precautions

Citric acid ingested frequently or in large quantities may cause erosion of the teeth and have a local irritant action.

💊 Interactions

Aluminium hydroxide.

Intestinal absorption of aluminium ions may be enhanced by oral doses of citrates. Caution is needed in patients with chronic renal disease receiving aluminium hydroxide as a phosphate binder who are given a calcium supplement in the form of effervescent tablets that contain citric acid.1
1. Mees EJD, Basçi A. Citric acid in calcium effervescent tablets may favour aluminium intoxication. Nephron 1991; 59: 322.

💊 Uses and Administration

Citric acid is used in effervescing mixtures; the monohydrate is used in the preparation of effervescent granules. Citric acid monohydrate is used as a synergist to enhance the effectiveness of antoxidants. Preparations containing citric acid are used in the management of dry mouth and to dissolve renal calculi, alkalinise the urine, and prevent encrustation of urinary catheters. Citric acid is an ingredient of citrated anticoagulant solutions. Citric acid has also been used in preparations for the treatment of coughs, gastrointestinal disturbances, and metabolic acidosis.

💊 Preparations

BP 2008: Lemon Syrup; Paediatric Compound Tolu Linctus; Paediatric Simple Linctus; Potassium Citrate Mixture; Simple Linctus; Ph. Eur.: Anticoagulant Acid-Citrate-Glucose Solutions (ACD); Anticoagulant Citrate-Phosphate-Glucose Solution (CPD); USP 31: Anticoagulant Citrate Dextrose Solution; Anticoagulant Citrate Phosphate Dextrose Adenine Solution; Anticoagulant Citrate Phosphate Dextrose Solution; Citric Acid, Magnesium Oxide, and Sodium Carbonate Irrigation; Magnesium Carbonate and Citric Acid for Oral Solution; Magnesium Carbonate, Citric Acid, and Potassium Citrate for Oral Solution; Magnesium Citrate Oral Solution; Potassium and Sodium Bicarbonates and Citric Acid Effervescent Tablets for Oral Solution; Potassium Citrate And Citric Acid Oral Solution; Sodium Citrate and Citric Acid Oral Solution; Tricitrates Oral Solution.

Proprietary Preparations

Gr.: Citrolithin; India: Revici; Mex.: Lipocinetic; Pol.: Citrolyt; S.Afr.: Crystacit; Venez.: Policitra. Multi-ingredient: Arg.: Alikal; Alka-Seltzer Doble Accion; Sal de Fruta Eno; Uvasal; Austral.: Alka-Seltzer; Citralite; Citravescent; Durolax XPack†; Eno; Picolax†; Picoprep; Ural; Uricalm†; Uricosal†; Austria: AlkaSeltzer; Duplotrast Z; Helo-acid; Kalioral; Belg.: Alka-Seltzer; Braz.: Citrosodine†; Digestbem; Regulador Xavier N-2†; Sal de Andrews; Sal de Fruta Eno; Sonrisal; Canad.: Alka-Seltzer; Bromo Madelon; Dicitrate†; PicoSalax; Chile: Disfruta; Fenokomp 39; Justegas†; Kanacitrin; Sal de Fruta Eno; Summer’s Eve Hierbas†; Uroalquine; Yasta; Cz.: Alka-Seltzer; Blemaren N; Carbocit; E-Z-Gas†; Herbadent; Fin.: Alka-Seltzer; Fr.: Alka-Seltzer; Citrocholine; Doculyse; Elixir Grez†; Hepargitol; Ornitaine; Sebium AKN; Sphingogel†; Ger.: Alka-Seltzer; Barilux Brausetabletten†; Blemaren N; Citropepsin†; Lithurex S†; Pepzitrat; Retterspitz Ausserlich; Retterspitz Innerlich; Uronor†; Gr.: E-Z-Gas; Gastrovison†; Hong Kong: Alka-Seltzer; Eno†; Hung.: Alka-Seltzer; Blemaren N; E-Z-Gas; Magurlit†; India: Carmicide; Coscopin; Coscopin Plus; Dristan Expectorant; Urisoda; Indon.: Koffex for Children; Promethazine Ikapharmindo; Irl.: Andrews; Carbex†; Cymalon; Mictral†; Israel: E-Z-Gas II; Eno; Urikal; Ital.: Alka-Seltzer; Citroepatina; Duogas; Geffer; Lavanda Sofar; Malaysia: Alka-Seltzer; Citravescent†; Ezee; Picoprep; Potcit; Ural; Mex.: Kaposalt; Lipo Slim N†; Uroclasio NF; Neth.: Alka-Seltzer; Gastrogas; NZ: Alka-Seltzer; Lemsip Dry Cough†; Picoprep; Ural; Philipp.: Alka-Seltzer; Pol.: Citropepsin; Port.: Alka-Seltzer; Creme Laser Hidrante; Detoxergon; Eno; Rus.: Alka-Seltzer (АлкаЗельтцер); Blemaren (Блемарен); S.Afr.: Adco-Sodasol; Alkafizz; Betasoda†; Citro-Soda; Citrocit†; Effersol; Pneucid; Quatro-Soda†; Uri-Alk; Vicks Cough Syrup; Singapore: Alka-Seltzer; Dicitrate; Potcit; Spain: Alka-Seltzer; Justegas; Pastillas Antisep Garg L; Sal de Fruta Eno; Sales de Frutas P G; Uralyt Urato; Swed.: Alka-Seltzer; Renapur; Switz.: Alka-Seltzer; E-Z-Gas II; Pepsi-Chlor†; Siesta-1; Thai.: Alka-Seltzer; Carmicide†; Turk.: Alka-Seltzer; UK: Alka-Seltzer; Alka-Seltzer XS; Allens Junior Cough; Andrews; Carbex; Cymalon; Effercitrate; Eno; Hill’s Balsam Chesty Cough for Children; Lemsip Cough & Cold Dry Cough; Potters Children’s Cough Pastilles; Resolve; Uriflex G; Uriflex R; Uro-Tainer Solution R; Uro-Tainer Suby G; Zubes Blackcurrant; Zubes Honey & Lemon; USA: Alka-Seltzer; Alka-Seltzer Antacid; Alka-Seltzer with Aspirin; Bicitra; Bromo Seltzer Effervescent Granules; Cytra-2; Cytra-3; Cytra-K; Cytra-LC; Extra Strength Alka-Seltzer Effervescent Tablets; Gold Alka-Seltzer; Oracit; Original Alka-Seltzer Effervescent Tablets; Polycitra; Polycitra-K; Polycitra-LC; Renacidin; Sparkles; Zee-Seltzer; Venez.: Alka-Seltzer; Eno.
Published April 18, 2019.