Ciliary Neurotrophic Factor

Synonyms: CNTF; Factor neurotrófico ciliar.
Cyrillic synonym: Цилиарный Нейротрофический Фактор.


Ciliary neurotrophic factor (CNTF) is a nerve growth factor produced in neural tissues and released in response to injury. Recombinant CNTF has been investigated in motor neurone disease, peripheral neuropathy, and obesity. CNTF is also under investigation for the treatment of retinitis pigmentosa and atrophic (dry) age-related macular degeneration as an intra-ocular polymer implant containing human retinal epithelial cells that have been genetically modified to secrete CNTF.
1. Miller RG, et al. A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis. Ann Neurol 1996; 39: 256–60
2. Ettinger MP, et al. Recombinant variant of ciliary neurotrophic factor for weight loss in obese adults: a randomized, dose-ranging study. JAMA 2003; 289: 1826–32
3. Sieving PA, et al. Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implants. Proc Natl Acad Sci U S A 2006; 103: 3896–901.
Published March 26, 2019.