Chondroitin Sulfate Sodium

(BAN, rINN)

💊 Chemical information

Chondroitin 4-Sulfate (chondroitin sulfate A); Chondroitin Sulphate Sodium; Chondroïtine, sulfate sodique de; Chondroitini natrii sulfas; Chondroitin-sulfát sodná sůl; Chondroityny sodu siarczan; CSA (chondroitin sulfate A); Sodium Chondroitin Sulfate; Sodyum Kondroitin Sülfat.
Chemical formula: (C14H19NO14SNa2) n .
CAS — 9007-28-7 (chondroitin sulfate); 9082-07-9 fate A); 39455-18-0 (chondroitin sulfate A sodium); 25322-46-7 (chondroitin sulfate C); 12678-07-8 (chondroitin sulfate C sodium).
ATC — M01AX25.
ATC Vet — QM01AX25.

Pharmacopoeias.

In Eur. and US.

Ph. Eur. 6.2

(Chondroitin Sulphate Sodium). A natural copolymer based mainly on the two disaccharides obtained from cartilage of both terrestrial and marine origins. Depending on the animal species of origin, it shows different proportions of 4-sulfate and 6-sulfate groups. A white or almost white, hygroscopic powder. Freely soluble in water; practically insoluble in alcohol and in acetone. A 5% solution in water has a pH of 5.5 to 7.5. Store in airtight containers. Protect from light.

USP 31

(Chondroitin Sulfate Sodium). The sodium salt of the sulfated linear glycosaminoglycan obtained from bovine, porcine, or avian cartilages of healthy and domestic animals used for food by humans. It consists mostly of the sodium salt of the sulfate ester of N-acetylchondrosamine (2-acetamido-2-deoxyβ-Dgalactopyranose) and D-glucuronic acid copolymer. These hexoses are alternately linked β-1,4 and β-1,3 in the polymer. Chondrosamine moieties in the prevalent glycosaminoglycan are monosulfated primarily on position 4 and less so on position 6. Chondroitin sulfate sodium is extremely hygroscopic once dried. Store in airtight containers.

💊 Profile

Chondroitin sulfate is an acid mucopolysaccharide that is a constituent of most cartilaginous tissues. It is used as the sodium salt, chondroitin sodium sulfate. It is given orally in reactive arthritides, such as gonococcal arthritis, and is sometimes given with glucosamine for its supposed chondroprotective action in bone, joint, and connective tissue disorders. It is also used for its visco-elastic properties as an adjunct to ocular surgical procedures, including cataract extraction and intra-ocular lens implantation, and has been used for the relief of dry eye. A medium containing chondroitin sulfate A has been used to preserve corneas for transplantation. Chondroitin sulfate sodium has also been used as a means of replacing the glycosaminoglycan layer in the bladder in the treatment of interstitial cystitis. Chondroitin sulfate A and C are components of the heparinoid danaparoid.

Osteoarthritis.

For references to the use of chondroitin in the treatment of osteoarthritis, including doubts about its value, see under Glucosamine.

💊 Preparations

USP 31: Chondroitin Sulfate Sodium Tablets; Glucosamine and Chondroitin Sulfate Sodium Tablets; Glucosamine, Chondroitin Sulfate Sodium, and Methylsulfonylmethane Tablets.

Proprietary Preparations

Arg.: Bioflogil; Condroitina†; Condrosulf†; Dunason; Liquiprin; Lubrictin; Norfisar†; Prof; Structum; Austria: Condrosulf; Belg.: Lacrypos; Braz.: Dunason; Canad.: Uracyst; Chile: Condro Sorb†; Condrosulf; Cz.: Condral; Condrosulf; Fr.: Chondrosulf; Lacrypos; Structum; Ger.: Uropol-S; Hung.: Condrosulf; Indon.: Viostin S; Malaysia: Chondril; Mex.: Condrosulf; Dunason; Maxus; Structum; Pol.: Condral; Recalcin; Port.: Condrosulf; Ossin; Rus.: Chondroitine-Akos (Хондроитин-Акос); Chondrolon (Хондролон)†; Structum (Структум); Spain: Condro San; Condrodin†; Condrosulf; Switz.: Condrosulf; Structum. Multi-ingredient: Arg.: Artrilase Complex; Artrocaptin; Asotrex; Baliartrin Duo; Cartiflex Forte; Ecosamina; Etinox; Finartrit; Findol Plus; Gluco Arrumalon Duo; Glucotrin VL; Lacrimax; Maxus; Mecanyl Duo; Optilac; Sigmaflex; Vartalon Duo; Viscoat; Austral.: Duovisc; GenFlex 3; GenFlex Plus; Viscoat; Braz.: Artrolive; Condroflex; Canad.: Uracyst Test Kit; Chile: Artridol Duo; Condrosamina†; Dinaflex Duo; Euroflex; Flexure; Hiperflex; Osteo Bi-Flex; Fr.: Viscoat; Ger.: Duovisc; Integra†; Viscoat; Hong Kong: Arthritil Plus; Duovisc†; Viscoat†; Hung.: Viscoat†; India: Cosantin†; Kondro; Osteocip; Osteoflex; Indon.: Aptivium Optimum Joint Formula; Artriox; Artritin; Bonic; Cartin Plus; Chondro-PA; Fitbon Plus; Flexor; Fripos; Joint Care; Jointfit; Maxitrin; Naturica Artro; Naturica Artro Plus; OA; OA Forte; OA Plus; Osamin; Oste; Ostela; Osteoflam; Osteokom; Osteokom Forte; Osteonic; Osteor; Osteor Plus; Osteor-C; Osvion Plus; Rheumatin; Rheumatin Forte; Triflexor; Triostee; Viopor; Viopor-M; Viostin Com; Viostin Com DS; Vosteon; Ital.: Cartago; Fitogenase; Joint Support; Reumilase SD; Viscoat; Malaysia: Duovisc; Viscoat; Mex.: Actiman; Artiflex; Vartalon Compositum; NZ: Viscoat; Philipp.: Flexxbon; Viscoat; Rus.: Artra (Артра); Chondroitine-Akos (Хондроитин-Акос); Chondroxide (Хондроксид); Theraflex (Терафлекс); S.Afr.: Duovisc; Viscoat; Singapore: Artril C; Duovisc; Flexeze†; Glutilage Plus; Seven Seas JointCare; Viscoat; Thai.: Duovisc; Viscoat; Turk.: Duovisc; Viscoat; UK: Flexeze; GlucOsamax; Joint Action; Jointace; USA: DisCoVisc; Viscoat; Venez.: Artrosamin; Viscoat†.
Published March 14, 2019.