Synonyms: Acide chénodésoxycholique; Ácido quenodeoxicólico; Acidum chenodeoxycholicum; CDCA; Chenic Acid; Chenodeoksicholio ru _ gštis; Chenodiol oolihappo; Kenodeoxicholsyra; Kenodezoxikólsav; Kyselina chenodeoxycholová. 3
Cyrillic synonym: Хенодезоксихолевая Кислота.
💊 Chemical information
Chemical formula: C24H40O4 = 392.6.
CAS — 474-25-9.
ATC — A05AA01.
ATC Vet — QA05AA01.
Pharmacopoeias.In Eur. and Jpn.
Ph. Eur. 6.2(Chenodeoxycholic Acid). A white or almost white powder. Very slightly soluble in water; freely soluble in alcohol; soluble in acetone; slightly soluble in dichloromethane.
💊 Adverse Effects and Precautions
As for Ursodeoxycholic Acid. Diarrhoea may occur more frequently than with ursodeoxycholic acid. A transient rise in liver-function test values and hypercholesterolaemia (lowdensity lipoprotein) have been reported with chenodeoxycholic acid. Chenodeoxycholic acid is embryotoxic in some animals.
As for Ursodeoxycholic Acid.
Chenodeoxycholic acid is absorbed from the gastrointestinal tract and undergoes first-pass metabolism and enterohepatic recycling. It is partly conjugated in the liver before being excreted into the bile and, under the influence of intestinal bacteria, the free and conjugated forms undergo 7 α-dehydroxylation to lithocholic acid. Some lithocholic acid is excreted directly in the faeces and the rest absorbed, mainly to be conjugated and sulfated by the liver before excretion in the faeces. Chenodeoxycholic acid also undergoes epimerisation to ursodeoxycholic acid.
1. Crosignani A, et al. Clinical pharmacokinetics of therapeutic bile acids. Clin Pharmacokinet 1996; 30: 333–58.
💊 Uses and Administration
Chenodeoxycholic acid is a naturally occurring bile acid. When given orally it reduces hepatic synthesis of cholesterol and provides additional bile salts to the pool available for solubilisation of cholesterol and lipids. It has been used for the dissolution of cholesterol-rich gallstones in patients with a functioning gallbladder, in usual doses of about 15 mg/kg daily. The daily dose may be divided unequally and the larger dose given before bedtime to counteract the increase in biliary cholesterol concentrations seen overnight. Treatment may need to be given for up to 2 years, depending on the size of the stone. It should be continued for about 3 months after radiological disappearance of the stones. Chenodeoxycholic acid is also used in reduced doses with ursodeoxycholic acid. Chenodeoxycholic acid has been used as a dietary supplement in neonates and children with inborn errors of bile acid synthesis: it has been used in the treatment of cerebrotendinous xanthomatosis; with cholesterol in the Smith-Lemli-Opitz syndrome; and with cholic acid for bile acid synthesis defects.
Austria: Chenofalk†; Belg.: Chenofalk†; Ger.: Chenofalk; Hong Kong: Chenofalk†; Hung.: Chenofalk†; Indon.: Chenofalk; Israel: Chenofalk; Soluston†; Mex.: Chenofalk†; Sulobil; Neth.: Chenofalk; Port.: Chebil†; Xebyl; Spain: Quenobilan; Quenocol†; Turk.: Chenofalk. Multi-ingredient: Austria: Lithofalk†; Ger.: Lithofalk; Urso Mix†; Gr.: Lithiofalk†; Ital.: Bilenor.
Published March 08, 2019.