Chaparral

(USAN, rINNM)

💊 Chemical information

Chaparral

💊 Profile

Chaparral is derived from the creosote bush, Larrea tridentata (Zygophyllaceae). It has been included in various herbal preparations but such use has been associated with severe hepatotoxicity. Recommendations that products containing chaparral should not be consumed have been made in several countries. Masoprocol is an antineoplastic isolated from the creosote bush.

Hepatotoxicity.

References.
1. Gordon DW, et al. Chaparral ingestion: the broadening spectrum of liver injury caused by herbal medications. JAMA 1995; 273: 489–90
2. Batchelor WB, et al. Chaparral-induced hepatic injury. Am J Gastroenterol 1995; 90: 831–3
3. Sheikh NM, et al. Chaparral-associated hepatotoxicity. Arch Intern Med 1997; 157: 913–19
4. Kauma H, et al. Toxic acute hepatitis and hepatic fibrosis after consumption of chaparral tablets. Scand J Gastroenterol 2004; 39: 1168–71.

💊 Preparations

Proprietary Preparations

Multi-ingredient: Austral.: Proyeast†.
Published March 06, 2019.