Synonyms: Caerulein; Cerulein; Ceruletid; Ceruletida; Cérulétide; Ceruletidum; FI-6934; 883-S; Seruletidi.
Cyrillic synonym: Церулетид.
💊 Chemical information
Chemical formula: C58H73N13O21S2 = 1352.4.
CAS — 17650-98-5 (ceruletide); 71247-25-1 (ceruletide diethylamine).
ATC — V04CC04.
ATC Vet — QV04CC04.
Description.Ceruletide is a decapeptide amide originally isolated from the skin of the Australian frog, Hyla caerulea, and other amphibians. Ceruletide may exist as a salt with 1 to 3 moles of diethylamine (ceruletide diethylamine).
💊 Adverse Effects
Ceruletide stimulates gallbladder contraction and gastrointestinal muscle and may give rise to abdominal discomfort. Hypotensive reactions may also occur.
💊 Uses and Administration
Ceruletide is structurally related to pancreozymin and has similar actions. When given parenterally it stimulates gallbladder contraction and relaxes the sphincter of Oddi; it also causes an increase in the secretion of pancreatic enzymes and stimulates intestinal muscle. As ceruletide diethylamine it is used as an aid to diagnostic radiology and in the management of paralytic ileus. It is also used in tests of pancreatic exocrine function, sometimes with secretin; these studies generally require duodenal intubation of the patient and examination of duodenal aspirate and are rarely performed. For most radiographic procedures of the biliary and digestive tracts ceruletide diethylamine is given by intramuscular injection in a dose equivalent to 300 nanograms/kg of ceruletide. Doses equivalent to 1 to 2 nanograms/kg per minute are given by intravenous infusion in pancreatic function tests and in the treatment of paralytic ileus.
Published March 01, 2019.