Castor Oil

(rINN)

💊 Chemical information

Aceite de Ricino; Hintyağı; Huile de Ricin; Ol. Ricin.; Oleum Ricini; Ricini Oleum; Ricini Oleum Virginale; Ricino, aceite de; Ricinolja sytöljy; Rizinusöl.
ATC — A06AB05.
ATC Vet — QA06AB05.

Pharmacopoeias.

In Chin., Eur., Jpn, and US. Eur. also includes hydrogenated castor oil and refined castor oil. USNF includes hydrogenated castor oil.

Ph. Eur. 6.2 (Castor Oil, Virgin). The fatty oil obtained by cold expression from the seeds of Ricinus communis. Relative density about 0.958. It is a clear, almost colourless or slightly yellow, viscous, hygroscopic liquid. Miscible with alcohol and with glacial acetic acid; slightly soluble in petroleum spirit. Store in wellfilled airtight containers. Protect from light.

Ph. Eur. 6.2 (Castor Oil, Hydrogenated; Ricini Oleum Hydrogenatum). The oil obtained by hydrogenation of castor oil. It consists mainly of the triglyceride of 12-hydroxystearic acid. Almost white to pale yellow fine powder, masses, or flakes. M.p. 83° to 88°. Practically insoluble in water and in petroleum spirit; very slightly soluble in dehydrated alcohol; slightly soluble in dichloromethane. Store in well-filled containers.

Ph. Eur. 6.2 (Castor Oil, Refined). The fatty oil obtained by cold expression from the seeds of Ricinus communis and then refined. A suitable antoxidant may be added. Relative density about 0.958. It is a clear, almost colourless or slightly yellow, viscous, hygroscopic liquid. Miscible with alcohol and with glacial acetic acid; slightly soluble in petroleum spirit. Store in well-filled, airtight containers. Protect from light.

USP 31

(Castor Oil). The fixed oil obtained from the seed of Ricinus communis (Euphorbiaceae). It is a pale yellowish or almost colourless, transparent, viscid liquid. Has a faint, mild odour; is free from foreign and rancid odour; and has a bland, characteristic taste. Soluble in alcohol; miscible with dehydrated alcohol, with chloroform, with ether, and with glacial acetic acid. Store in airtight containers at a temperature not exceeding 40°.

USNF 26

(Hydrogenated Castor Oil). Refined, bleached, hydrogenated, and deodorised castor oil, consisting mainly of the triglyceride of hydroxystearic acid. A white, crystalline wax. M.p. 85° to 88°. Insoluble in water and in most common organic solvents. Store in airtight containers at a temperature not exceeding 40°.

💊 Adverse Effects and Precautions

Oral administration of castor oil, particularly in large doses, may produce nausea, vomiting, colic, and severe purgation. Castor oil should not be given when intestinal obstruction is present. The seeds of Ricinus communis contain a toxic protein, ricin. Allergic reactions have been reported in subjects handling the seeds.

💊 Uses and Administration

Castor oil is used externally for its emollient effect. It has also been used topically to allay irritation due to foreign bodies in the eye. Castor oil may be employed as the solvent in some injections. Hydrogenated castor oil is used as a stiffening agent. Polyoxyl castor oils are used as emulsifying and solubilising agents. Castor oil has been used as a laxative, but such use is obsolete.

💊 Preparations

BP 2008: Chloroxylenol Solution; Flexible Collodion; Zinc and Castor Oil Ointment; USP 31: Aromatic Castor Oil; Castor Oil Capsules; Castor Oil Emulsion; Flexible Collodion.

Proprietary Preparations

Arg.: Capsulas Handel†; Braz.: Laxol; Canad.: Neoloid†; Ger.: Laxopol; Gr.: Kikelaio EF 3†; Israel: Laxopol; Mex.: Ricitel; Switz.: Herbapharm Rical†; Rical; Turk.: Ricilaks; Ricipan; USA: Emulsoil; Neoloid; Purge†. Multi-ingredient: Arg.: Calculina†; Austral.: Seda-Rash†; Chile: Node DS; Cz.: Suspensio Visnevski cum Pice Liquida Herbacos; Mex.: Nutegen G†; Pol.: Salicylol; Spain: Otocerum; Switz.: Peru Stick; USA: AllandermT; Dermuspray; Dr Dermi-Heal; Granulderm; Granulex; GranuMed; Mammol; Proderm; Xenaderm.
Published February 12, 2019.