Caroverine

(pINN)
Caroverine Chemical formula
Synonyms: Caroverina; Carovérine; Caroverinum. 1-[2-(Diethylamino)ethyl]-3-(p-methoxybenzyl)-2(1H)-quinoxalinone.
Cyrillic synonym: Кароверин.

💊 Chemical information

Chemical formula: C22H27N3O2 = 365.5.
CAS — 23465-76-1.
ATC — A03AX11.
ATC Vet — QA03AX11.

💊 Profile

Caroverine is a smooth muscle relaxant with calcium-channel blocking and glutamate-antagonist properties. It is used as the base or the hydrochloride in conditions associated with painful smooth muscle spasm. Typical doses (expressed as the base) are 20 to 40 mg by mouth three or four times daily. It may also be given by slow intravenous or intramuscular injection in doses of 40 to 80 mg. Caroverine has also been given rectally. It is also used in cerebral circulatory disorders and in tinnitus.
1. Denk DM, et al. Caroverine in tinnitus treatment: a placebo-controlled blind study. Acta Otolaryngol 1997; 117: 825–30
2. Ehrenberger K. Clinical experience with caroverine in inner ear diseases. Adv Otorhinolaryngol 2002; 59: 156–62
3. Quint C, et al. The quinoxaline derivative caroverine in the treatment of sensorineural smell disorders: a proof-of-concept study. Acta Otolaryngol 2002; 122: 877–81.

💊 Preparations

Proprietary Preparations

Austria: Delirex; Spasmium; Tinnitin; Switz.: Calmaverine†. Multi-ingredient: Austria: Spagall; Spasmium comp.
Published February 07, 2019.