Calcium Dobesilate

Calcium Dobesilate Chemical formula
Synonyms: Calcii dobesilas; Calcium, dobésilate de; Calcium Doxybenzylate; CLS-2210; Dobesilan vápenatý; Dobésilate de Calcium; Dobesilato de calcio; 205E; Kalcio dobesilatas; Kalciumdobesilat; Kalcium-dobezilát; Kalsiumdobesilaatti; Kalsiyum Dobesilat. Calcium 2,5-dihydroxybenzenesulphonate.
Cyrillic synonym: Кальция Добезилат.

💊 Chemical information

Chemical formula: C12H10CaO10S2 = 418.4.
CAS — 88-46-0 (dobesilic acid); 20123-80-2 (calcium dobesilate).
ATC — C05 BX01.
ATC Vet — QC05BX01.


In Eur. which specifies the monohydrate.

Ph. Eur. 6.2

(Calcium Dobesilate Monohydrate). A white or almost white hygroscopic powder. Very soluble in water; freely soluble in dehydrated alcohol; practically insoluble in dichloromethane; very slightly soluble in isopropyl alcohol. A 10% solution in water has a pH of 4.5 to 6.0. Store in airtight containers. Protect from light.

💊 Profile

Calcium dobesilate is claimed to reduce capillary permeability and has been used in various peripheral circulatory disorders including diabetic retinopathy and haemorrhoids. Gastrointestinal disturbances have occurred with its use, and there are also reports of hypersensitivity reactions. Calcium dobesilate is given orally in usual doses of 0.5 to 1.5 g daily in divided doses. It is also given rectally for haemorrhoids and is an ingredient of some preparations given for various skin disorders.
1. Tejerina T, Ruiz E. Calcium dobesilate: pharmacology and future approaches. Gen Pharmacol 1998; 31: 357–60
2. Berthet P, et al. Calcium dobesilate: pharmacological profile related to its use in diabetic retinopathy. Int J Clin Pract 1999; 53: 631–6.

Adverse effects.

Agranulocytosis has been reported1-3 in a few patients after treatment with calcium dobesilate, and in 2 cases recurred on rechallenge.1,2 However, a later review4 of the safety profile of calcium dobesilate concluded that the overall risk of adverse effects was low with the most prominent symptoms being fever, arthralgias, and gastrointestinal disturbances. Reports of agranulocytosis were rare and the authors concluded that there may have been methodological bias in previous assessments of risk.
1. Kulessa W, et al. Wiederholte Agranulozytose nach Einnahme von Calciumdobesilat. Dtsch Med Wochenschr 1992; 117: 372–4
2. Cladera Serra A, et al. Agranulocitosis inducida por dobesilato calcico. Med Clin (Barc) 1995; 105: 558–9
3. García Benayas E, et al. Calcium dobesilate-induced agranulocytosis. Pharm World Sci 1997; 19: 251–2
4. Allain H, et al. Safety of calcium dobesilate in chronic venous disease, diabetic retinopathy and haemorrhoids. Drug Safety 2004; 27: 649–60.

💊 Preparations

Proprietary Preparations

Arg.: Doxium; Duflemina†; Eflevar; Austria: Doxium; Vasactin; Chile: Doxium; Cz.: Danium; Dobica; Doxium; Ger.: Dexium; Dobica; Gr.: Doxytrex; Nugatex; Hong Kong: Dobesifar†; Doxium; Hung.: Doxilek; Doxium; India: Dobilet; Ital.: Doxium; Malaysia: Doxium; Mex.: Doxium; Philipp.: Doxium; Pol.: Doxium; Port.: Doxi-Om; Rus.: Doxi-Hem (Докси-хем); S.Afr.: Doxium; Spain: Doxium; Switz.: Doxium; Tu rk.: Doxium; Venez.: Deoxical; Doxium. Multi-ingredient: Arg.: Vasodual†; Cz.: Danium Compositum†; Dobexil; Dobexil Plus†; Doxiproct; Doxiproct Plus; Doxivenil†; Hung.: Doxiproct; Doxiproct Plus; Doxivenil; Ital.: Doxiproct; Mex.: Doxiproct Plus; Doxiproct†; Port.: Doxiproct; Doxiproct Plus; Doxivenil; Spain: Acnisdin; Acnisdin Retinoico; Proctium; Switz.: Doxiproct; Doxiproct Plus; Doxivenil; Venez.: Doxivenil.
Published February 01, 2019.