Calcium Carbimide

(rINN)
Calcium Carbimide Chemical formula
Synonyms: Calcii Carbimidum; Calcium Cyanamide; Carbimida cálcica; Carbimide Calcique; Cyanamide.
Cyrillic synonym: Кальция Карбимид.

💊 Chemical information

Chemical formula: CCaN2 = 80.1.
CAS — 156-62-7 (calcium carbimide); 8013-88-5 (citrated calcium carbimide).
ATC — N07BB02.
ATC Vet — QN07BB02; QV03AA02.
NOTE. The name cyanamide is also used to designate carbimide, which is used in veterinary medicine.

💊 Adverse Effects and Precautions

Calcium carbimide may cause drowsiness, dizziness, fatigue, skin rash, tinnitus, depression, impotence, and urinary frequency. There may be a reversible increase in the white cell count. It should be used with caution in patients with asthma, coronary artery disease, or myocardial disease. Calcium carbimide causes a reaction in patients who have consumed alcohol similar to that seen with disulfiram.

Effects on the heart.

Hypotension and tachycardia were reported during the carbimide-alcohol reaction.1
1. Peachey JE, et al. Cardiovascular changes during the calcium carbimide-ethanol interaction. Clin Pharmacol Ther 1981; 29: 40–6.

Effects on the liver.

Reports1,2 of hepatic lesions in patients receiving calcium carbimide.
1. Vázquez JJ, Cervera S. Cyanamide-induced liver injury in alcoholics. Lancet 1980; i: 361–2
2. Moreno A, et al. Structural hepatic changes associated with cyanamide treatment: cholangiolar proliferation, fibrosis and cirrhosis. Liver 1984; 4: 15–21.

💊 Uses and Administration

Calcium carbimide has actions and uses similar to those of disulfiram. It is an aversive agent used as an adjunct in the treatment of chronic alcoholism. It is given in a dose of up to 60 mg twice daily by mouth. Citrated calcium carbimide has been used similarly.
1. Peachey JE, et al. A comparative review of the pharmacological and toxicological properties of disulfiram and calcium carbimide. J Clin Psychopharmacol 1981; 1: 21–6.

💊 Preparations

Proprietary Preparations

Austria: Colme; Rus.: Colme (Колме); Spain: Colme.
Published January 31, 2019.