Cadmium Sulfate

(rINNM)

💊 Chemical information

Cadmii sulfas; Cadmium, sulfate de; Kadmiumsulfaatti; Kadmiumsulfat; Kadmu siarczan.
Chemical formula: CdSO4 = 208.5.
CAS — 10124-36-4.
pathicas). A white or almost white, crystalline powder. Freely soluble in water; practically insoluble in alcohol.

💊 Profile

Cadmium is used in a wide range of manufacturing processes and cadmium poisoning presents a recognised industrial hazard. Inhalation of cadmium fumes during welding procedures may not produce symptoms until 12 to 36 hours have passed and these symptoms include respiratory distress leading to pulmonary oedema; kidney toxicity is also a feature of acute cadmium poisoning. Ingestion of cadmium or its salts has the additional hazard of severe gastrointestinal effects. Cadmium has a long biological half-life and accumulates in body tissues, particularly the liver and kidneys. Chelation therapy is not generally recommended for cadmium poisoning, although sodium calcium edetate has been used after acute ingestion. However, chelators do not increase cadmium elimination in chronic poisoning and use of dimercaprol may increase cadmium toxicity and should be avoided. Chronic exposure to cadmium results in progressive renal impairment and other effects (see below). Cadmium sulfide has been used topically in some countries for the treatment of skin and scalp conditions. Cadmium sulfate has been included in some preparations for the treatment of eye irritation.

Homoeopathy.

Cadmium has been used in homoeopathic medicines under the following names: Cadmium metallicum; Cad. met. Cadmium sulfate has been used in homoeopathic medicines under the following names: Cadmium sulfuricum; Cadmium sulphuricum; Cad. sul. Cadmium sulphide has been used in homoeopathic medicines under the following names: Cadmium sulphuratum; Cad. sulph.

Adverse effects.

The toxicity of cadmium has been reviewed.1Environmental or occupational exposure to cadmium has been associated with renal dysfunction,2-5 although this may be reversible if exposure is reduced.6 A reduction in bone density may also occur.7 Fatalities due to industrial exposure or self-poisoning have also been reported.8,9 No effect on testicular endocrine function was observed in 77 industrial workers exposed to cadmium.3 An increased incidence of cancer of the prostate has been reported in subjects exposed to high levels of cadmium but the evidence is not conclusive.10 There may be an association between cadmium exposure and lung cancer, although observations on this type of cancer are difficult to interpret because of exposure to other hazards such as smoking.
1. Fielder RJ, Dale EA. Cadmium and its compounds. Toxicity Revie
7. London: HMSO, 1983
2. Buchet JP, et al. Renal effects of cadmium body burden of the general population. Lancet 1990; 336: 699–702. Correction. ibid. 1991; 337: 1554
3. Mason HJ. Occupational cadmium exposure and testicular endocrine function. Hum Exp Toxicol 1990; 9: 91–4
4. Cai S, et al. Renal dysfunction from cadmium contamination of irrigation water: dose-response analysis in a Chinese population. Bull WHO 1998; 76: 153–9
5. Satarug S, et al. Safe levels of cadmium intake to prevent renal toxicity in human subjects. Br J Nutr 2000; 84: 791–802
6. Hotz P, et al. Renal effects of low-level environmental cadmium exposure: 5-year follow-up of a subcohort from the Cadmibel study. Lancet 1999; 354: 1508–13
7. Staessen JA, et al. Environmental exposure to cadmium, forearm bone density, and risk of fractures: prospective population study. Lancet 1999; 353: 1140–44
8. Taylor A, et al. Poisoning with cadmium fumes after smelting lead. BMJ 1984; 288: 1270–1
9. Buckler HM, et al. Self poisoning with oral cadmium chloride. BMJ 1986; 292: 1559–60. Correction. ibid.; 293: 236
10. Bell GM. Carcinogenicity of cadmium and its compounds. Toxicity Revie
24. London: HMSO, 1991.

💊 Preparations

Proprietary Preparations

Spain: Biocadmio.
Published January 30, 2019.