Synonyms: Buphénine, Chlorhydrate de; Buphenini Hydrochloridum; Hidrocloruro de bufenina; Nylidrin Hydrochloride; Nylidrinium Chloride. 1-(4-Hydroxyphenyl)-2-(1-methyl-3-phenylpropylamino)propan-1-ol hydrochloride.
Cyrillic synonym: Буфенина Гидрохлорид.
💊 Chemical information
Chemical formula: C19H25NO2,HCl = 335.9.
CAS — 447-41-6 (buphenine); 849-55-8 (buphenine hydrochloride).
ATC — C04AA02; G02CA02.
ATC Vet — QC04AA02; QG02CA02.
💊 Adverse Effects and Precautions
As for Sympathomimetics; buphenine has mainly betaagonist effects.
💊 Uses and Administration
Buphenine produces peripheral vasodilatation through betaadrenoceptor stimulation and a direct action on the arteries and arterioles of the skeletal muscles. Buphenine has been used in the treatment of peripheral vascular and cerebrovascular disease. It has also been used in preparations for rhinitis and nasal congestion. Doses of buphenine hydrochloride in the range of 3 to 12 mg three or four times daily have been given orally. An intravenous infusion of buphenine hydrochloride has been used to arrest premature labour. It has also been given orally as a prophylactic tocolytic agent.
Austria: Dilatol; Canad.: Arlidin; India: Arlidin; Mex.: Arlidin; Nilken; Switz.: To c o d r i n e † . Multi-ingredient: Austria: Arbid; Dilaescol; Dilatol-Chinin; Opino; Tropoderm; Fr.: Ophtadil†; Phlebogel; Ger.: Apoplectal N†; opino N spezial†; Gr.: Opino-jel; Indon.: Opino; Mex.: Flumil; Switz.: Arbid; Visaline.
Published January 28, 2019.