Bucillamine

(rINN)
Bucillamine Chemical formula
Synonyms: Bucilamina; Bucillaminum; DE-019; SA-96; Tiobutarit. N-(2-Mercapto-2-methylpropionyl)
Cyrillic synonym: Буцилламин.

💊 Chemical information

Chemical formula: C7H13NO3S2 = 223.3.
CAS — 65002-17-7.
ATC — M01 CC02.
ATC Vet — QM01CC02.

Pharmacopoeias.

In Jpn.

💊 Profile

Bucillamine is structurally related to penicillamine and is reported to be an immunomodulator that has been used in the treatment of rheumatoid arthritis.

Adverse effects.

Bucillamine has been implicated in the development of skin,1 kidney,2,3 and lung disorders.4
1. Ogata K, et al. Drug-induced pemphigus foliaceus with features of pemphigus vulgaris. Br J Dermatol 2001; 144: 421–2
2. Nagahama K, et al. Bucillamine induces membranous glomerulonephritis. Am J Kidney Dis 2002; 39: 706–12
3. Hoshino J, et al. Outcome and treatment of bucillamine-induced nephropathy. Nephron Clin Pract 2006; 104: c15–c19
4. Saito Y, et al. A case of bucillamine-induced interstitial pneumonia with positive lymphocyte stimulation test for bucillamine using bronchoalveolar lavage lymphocytes. Intern Med 2007; 46: 1739–43.

💊 Preparations

Proprietary Preparations

Jpn: Rimatil.
Published January 27, 2019.