Bentiromide

(BAN, USAN, rINN)
Bentiromide Chemical formula
Synonyms: Bentiromid; Bentiromida; Bentiromidi; Bentiromidum; BTPABA; BT-PABA; E-2663; PFT; Ro-11-7891. 4-(N-Benzoylno)benzoic acid.
Cyrillic synonym: Бентиромид.

Chemical information

Chemical formula: C23H20N2O5 = 404.4.
CAS — 37106-97-1.
ATC — V04CK03.
ATC Vet — QV04CK03.

Profile

Bentiromide has been given orally as a noninvasive test of exocrine pancreatic function, the amount of p-aminobenzoic acid and its metabolites excreted in the urine being taken as a measure of the chymotrypsin-secreting activity of the pancreas. Headache and gastrointestinal disturbances have been reported in patients receiving bentiromide. The bentiromide test has given misleading results in patients with gastrointestinal, liver, or kidney disorders, or in patients receiving certain foods or drugs that are excreted as arylamines. Some of these drugs included benzocaine, chloramphenicol, lidocaine, paracetamol, procaine, procainamide, sulfonamides, and some diuretics.
1. Hoek FJ, et al. Improved specificity of the PABA test with paminosalicylic acid (PAS). Gut 1987; 28: 468–73
2. Puntis JWL, et al. Simplified oral pancreatic function test. Arch Dis Child 1988; 63: 780–4.
Published January 11, 2019.