Belladonna

(BAN, USAN, rINN)

💊 Chemical information

Belladon; Belladona; Belladone; Belladone, feuille de (belladonna leaf); Belladonnablad (belladonna leaf); Belladonnae folium (belladonna leaf); Belladonnanlehti (belladonna leaf); Deadly Nightshade; Liść pokrzyku (belladonna leaf); Nadragulyalevél (belladonna leaf); Rulíkový list (belladonna leaf); Šunvyšniu lapai (belladonna leaf); Tollkirschen.
ATC — A03BA04.
ATC Vet — QA03BA04.

Pharmacopoeias.

Eur. and US include a monograph for Belladonna Leaf. Chin. includes Belladonna Herb. Eur. also includes Prepared Belladonna Leaf, Standardised Belladonna Leaf Tincture, and Standardised Belladonna Leaf Dry Extract. Jpn includes only Belladonna Root.

Ph. Eur. 6.2 (Belladonna Leaf; Belladonnae Folium). It consists of the dried leaf, or dried leaf and flowering, and occasionally fruitbearing, tops of Atropa belladonna. It contains not less than 0.30% of total alkaloids, calculated as hyoscyamine. The alkaloids consist mainly of hyoscyamine together with smaller amounts of hyoscine. It has a slightly nauseous odour. Protect from light. The BP 2008 directs that when Belladonna Herb, Belladonna Leaf, or Powdered Belladonna Herb is prescribed, Prepared Belladonna Herb shall be dispensed.

Ph. Eur. 6.2 (Belladonna, Prepared; Belladonnae Pulvis Normatus; Prepared Belladonna Herb BP 2008). It is belladonna leaf powder adjusted to an alkaloidal content of 0.28 to 0.32% of total alkaloids, calculated as hyoscyamine. Store in airtight containers. Protect from light.

USP 31

(Belladonna Leaf). It consists of the dried leaf and flowering or fruiting top of Atropa belladonna (Solanaceae). It yields not less than 0.35% of the alkaloids of belladonna leaf. When moistened, its odour is slight, somewhat tobacco-like. Avoid long exposure to direct sunlight. Protect powdered Belladonna Leaf from light.

Stability in mixtures.

Atropine in belladonna preparations was unstable at alkaline pH and would quickly be degraded in mixtures with a pH above 7. 1 Such mixtures in the BPC 1973 included Aluminium Hydroxide and Belladonna Mixture, Cascara and Belladonna Mixture, and Magnesium Trisilicate and Belladonna Mixture. 1. PSGB Lab Report P/71/9 1971.

💊 Adverse Effects, Treatment, and Precautions

💊 Interactions

As for antimuscarinics in general.

💊 Uses and Administration

Belladonna has the actions of atropine. Belladonna herb and its preparations have been used for their antimuscarinic actions in a wide range of conditions, including the relief of gastrointestinal and urinary-tract disorders associated with smooth muscle spasm, but they are generally regarded as an outmoded form of treatment. Belladonna liniments and plasters have been used as counterirritants for the relief of pain but there is little evidence that they have a beneficial effect and adverse effects have occurred.

Homoeopathy.

Belladonna has been used in homoeopathic medicines under the following names: Atropa bella-donna; Bell.

💊 Preparations

Ph. Eur.: Belladonna Leaf Dry Extract, Standardised; Belladonna Leaf Tincture, Standardised; USP 31: Belladonna Extract; Belladonna Extract Tablets; Belladonna Tincture.

Proprietary Preparations

Austral.: Atrobel†; Austria: Bellanorm; Chile: Felaxen†; Ger.: Belladonnysat Burger; Tremoforat†; Pol.: Bellapan; Venez.: Atroveran. Multi-ingredient: Arg.: Antipasmol; Benitol; Cascara Sagrada Bouzen†; Cascara Sagrada Oligoplex; Dioxicolagol; Hepacur; Hepatodirectol; Opobyl; Passacanthine†; Trixol†; Austria: Asthma 23 D; Tampositorien mit Belladonna; Belg.: Colimax†; Eucalyptine Pholcodine Le Brun†; Gastrofilm†; Grains de Vals; Saintbois; Braz.: Acridin; Benzomel†; Bisuisan†; Broncol; Bronquidex; Brontoss; Calminex Atleta; Calminex H; Cessatosse†; Cystex; Dorveran†; Ductoveran; Etaverol†; Gastrobene; Gotas Nican†; Iodeto de Potassio†; Pilulas Ross; Regulador Xavier N-1†; Regulador Xavier N-2†; Revulsan†; Salicilato de Bismuto Composto†; Solvobil; Teutoss†; Tussifen†; Tussucalman†; Xarope de Caraguata†; Xarope Sao Joao†; Canad.: Bellergal; Cafergot-PB†; Rheumalan†; Chile: Bellergal Retardado†; Belupan†; Broncodeina; Cafergot-PB†; Ergobelan; Fenokomp 39; Fenolftaleina Compuesta†; Gotas Nican†; Gruben; Ramistos; Cz.: Bellaspon†; Capsicolle; Contraspan†; Homeovox; Denm.: Gynergen Comp; Fin.: Tannopon; Fr.: Gelumaline†; Humex†; Suppomaline; Ger.: Dalet Med Balsam†; Hung.: Artin†; Kefalgin; India: Emantid†; Migranil; Molzyme†; Indon.: Bellapheen; Spasmal; Spasminal; Stomadon; Israel: Laxative; Laxative Comp; Ital.: Antiemorroidali; Antispasmina Colica; Lassatina†; Jpn: Colgen Kowa Bien Soft Mini; Mex.: Chofabol; Parche Negro Belladona; Reudol; Pol.: Alax; Bellergot; Biospasmil; Cholitol; Hemorol; Kapsiplast; Spasticol; Port.: Anti-Gripe†; Antispasmina Colica; Anucet†; Balsamo Analgesico Sanitas; Migretil; Servetinal†; Vaporil; Rus.: Anusol (Анузол); Bethiol (Бетиол); Solutan (Солутан); S.Afr.: Bennetts Colic Mixture; Bolus Eucalypti Comp; Cafergot-PB†; Spain: Alofedina; Boldolaxin†; Broncovital†; Cafergot-PB†; Carminativo Juventus; Crislaxo; Digestovital†; Dolokey; Equidan†; Laxante Bescansa Aloico; Menabil Complex†; Sin Mareo x 4; Tanagel; Switz.: Bellagotin†; Bromocod N; Cafergot-PB; Demo Elixir pectoral N; Dragees S contre la toux†; Escotussin; Lysedil; Nican; Phol-Tux; Saintbois; Thai.: Belacid; Bellergal†; Benera; Delta Charcoal; Neuramizone; Turk.: Bellergal; UK: Opazimes; USA: B & O Supprettes No. 15A; B & O Supprettes No. 16A; Bel-PhenErgot S; Bellamine; Bellergal-S; Butibel; Cafatine-PB; Folergot-DF; Phenerbel-S; Venez.: Atrobel; Cloverin†; Codoformo†; Ervostal; Neo-Atropan†; Traveget.
Published January 10, 2019.