Anisodamine

(rINN)

Chemical information

6-Hydroxy-hyoscyamine.
Chemical formula: C17H23NO4 = 305.4.
CAS — 55869-99-3.

Pharmacopoeias.

Chin. has a monograph for Raceanisodamine and Anisodamine Hydrobromide.

Profile

Anisodamine is an alkaloid isolated from Scopolia tangutica (Anisodus tanguticus), a plant used as a traditional medicine in China. It is related to atropine and hyoscyamine and has similar antimuscarinic properties. Anisodamine is given orally for its spasmolytic actions in the treatment of gastrointestinal spasm. It has also been tried in circulatory disorders, septic shock, and organophosphorus poisoning.
1. Poupko JM, et al. The pharmacological properties of anisodamine. J Appl Toxicol 2007; 27: 116–21
2. Fu XH, et al. Effect of intracoronary administration of anisodamine on slow reflow phenomenon following primary percutaneous coronary intervention in patients with acute myocardial infarction. Chin Med J (Engl) 2007; 120: 1226–31.
Published December 22, 2018.