Anecortave

(rINN)
Anecortave Chemical formula
Synonyms: AL-3789; Anecortava; Anécortave; Anecortave Acetate (USAN); Anecortavum. 17,21-Dihydroxypregna-4,9(11)-diene-3,20-dione 21-acetate.
Cyrillic synonym: Анекортав.

Chemical information

Chemical formula: C23H30O5 = 386.5.
CAS — 7753-60-8.
ATC — S01LA02.
ATC Vet — QS01LA02.

Profile

Anecortave is an angiostatic cortisene under investigation for the treatment of patients with neovascular (wet) age-related macular degeneration. It is similar in structure to cortisol acetate but without any glucocorticoid activity and is able to inhibit several steps of the neovascularisation process. It is given by posterior juxtascleral depot injection and is available in some countries for compassionate use on a named-patient basis.
1. Clark AF. Mechanism of action of the angiostatic cortisene anecortave acetate. Surv Ophthalmol 2007; 52 (suppl 1): S26–S34
2. Regillo CD, et al. Clinical safety profile of posterior juxtascleral depot administration of anecortave acetate 15 mg suspension as primary therapy or adjunctive therapy with photodynamic therapy for treatment of wet age-related macular degeneration. Surv Ophthalmol 2007; 52 (suppl 1): S70–S78
3. Russell SR, et al. Anecortave acetate for the treatment of exudative age-related macular degeneration—a review of clinical outcomes. Surv Ophthalmol 2007; 52 (suppl 1): S79–S90
4. Geltzer A, et al. Surgical implantation of steroids with antiangiogenic characteristics for treating neovascular age-related macular degeneration. Available in The Cochrane Database of Systematic Reviews; Issu
4. Chichester: John Wiley; 2007 (accessed 08/04/08).
Published December 17, 2018.