Amylase

(BAN, rINN)

💊 Chemical information

Amilasa; Amylaza; Diastase; Glucogenase; Ptyalin.
CAS — 9000-92-4 (amylase); 9000-85-5 (bacterial amylase); 9000-90-2 (porcine -amylase, pancreatic); 9001-19-8 (taka-diastase);.
ATC — A09AA01.
ATC Vet — QA09AA01.

Pharmacopoeias.

In Fr. and Jpn.

💊 Adverse Effects

Hypersensitivity reactions have been reported.

Hypersensitivity.

References to asthma developing after occupational exposure to amylases used in the flour milling1-3 and detergent4,5 manufacturing industries, and studies6-8 to assess the likelihood of developing amylase hypersensitivity after ingesting wheat products including bread.
1. Smith TA, et al. Respiratory symptoms and wheat flour exposure: a study of flour millers. Occup Med (Lond) 2000; 50: 25–9
2. Cullinan P, et al. Allergen and dust exposure as determinants of work-related symptoms and sensitization in a cohort of flour-exposed workers; a case-control analysis. Ann Occup Hyg 2001; 45: 97–103
3. Quirce S, et al. Glucoamylase: another fungal enzyme associated with baker’s asthma. Ann Allergy Asthma Immunol 2002; 89: 197–202
4. Hole AM, et al. Occupational asthma caused by bacillary amylase used in the detergent industry. Occup Environ Med 2000; 57: 840–2
5. Cullinan P, et al. An outbreak of asthma in a modern detergent factory. Lancet 2000; 356: 1899–1900
6. Cullinan P, et al. Clinical responses to ingested fungal alphaamylase and hemicellulase in persons sensitized to Aspergillus fumigatus? Allergy 1997; 52: 346–9
7. Sander I, et al. Is fungal alpha-amylase in bread an allergen? Clin Exp Allergy 2000; 30: 560–5
8. Simonato B, et al. IgE binding to soluble and insoluble wheat flour proteins in atopic and non-atopic patients suffering from gastrointestinal symptoms after wheat ingestion. Clin Exp Allergy 2001; 31: 1771–8.

💊 Uses and Administration

The term amylase refers to an enzyme catalysing the hydrolysis of
α-1,4-glucosidic linkages of polysaccharides such as starch,
glycogen, or their degradation products. Amylases may be classified according to the manner in which the glucosidic bond is attacked. Endoamylases attack the α-1,4-glucosidic linkage at random. Alpha-amylases are the only types of endoamylases known and yield dextrins, oligosaccharides, and monosaccharides. The more common alpha-amylases include those isolated from human saliva, mammalian pancreas, Bacillus subtilis, Aspergillus oryzae, and barley malt. Exoamylases attack the α-1,4glucosidic linkage only from the non-reducing outer polysaccharide chain ends. They include beta-amylases and glucoamylases (amyloglucosidases or gamma-amylases) and are of vegetable or microbial origin. Beta-amylases yield beta-limit dextrins and maltose, and glucoamylases yield glucose. Amylase is used in the production of predigested starchy foods and for the conversion of starch to fermentable sugars in the baking, brewing, and fermentation industries. Amylase from various sources has been used as an ingredient of preparations of mixed digestive enzymes, and has been given by mouth for its supposed activity in reducing respiratory-tract inflammation and local swelling and oedema. Pancreatic enzymes such as pancreatin and pancrelipase have amylase activity.

💊 Preparations

Proprietary Preparations

Cz.: Orenzym; Fr.: Flaviastase; Maxilase; Megamylase; Ribamylase; Port.: Maxilase. Multi-ingredient: Arg.: Docechol; Dom-Polienzim; Gastridin-E; Homocisteon Compuesto; Pakinase; Polienzim; Tridigestivo Soubeiran; Austral.: Enzyme; Austria: Wobenzym; Belg.: Digestomen; Braz.: Bromelin†; Enziprid†; Essen; Filogaster†; Pantopept†; Primeral; Thiomucase; Canad.: Digesta; Chile: Flapex E; Cz.: Wobenzym; Ger.: Enzym-Wied†; Hong Kong: Digezym; Enzyplex; Magesto; India: Aristozyme; Bestozyme; Catazyme-P; Digeplex; Digeplex-T; Dipep; Farizym; Lupizyme; Molzyme†; Neopeptine; Nutrozyme; Papytazyme; Sanzyme-DS; Unienzyme; Vitazyme; Indon.: Aludonna; Enzyplex; Excelase-E; Librozym; Librozym Plus; Vitazym; Xepazym; Ital.: Digestopan†; Essen Enzimatico†; Jpn: Cabagin; Malaysia: Biotase; Enzyplex; Pepfiz; Mex.: Ochozim; Wobenzym; Zimotris; Port.: Modulanzime; Rus.: Pepfiz (Пепфиз); Wobenzym (Вобэнзим); Singapore: Biotase; Enzyplex; Weisen-U†; Spain: Demusin; Digestomen Complex; Paidozim; Switz.: Zymoplex†; Thai.: Diasgest; Digestin; Endogest†; Enzyplex; Flatulence; Magesto; Mesto-Of; Papytazyme†; Pepfiz; Pepsitase; Polyenzyme-I; UK: Enzyme Digest; Enzyme Plus; USA: Enzyme; Ku-Zyme; Kutrase; Papaya Enzyme; Venez.: Festal Reformulado.
Published December 15, 2018.