💊 Chemical information
Acidum Aminohippuricum; p-Aminobenzoylglycine; p-Aminohippuric Acid; Aminohippurihappo; Aminohippursyra; Aminohipúrico, ácido; Kwas aminohipurowy; PAHA; Para-aminohippuric Acid. N4-Aminobenzoylaminoacetic acid.
Chemical formula: C9H10N2O3 = 194.2.
CAS — 61-78-9 (aminohippuric acid); 94-16-6 (sodium aminohippurate).
ATC — V04CH30.
ATC Vet — QV04CH30.
USP 31(Aminohippuric Acid). A white crystalline powder which discolours on exposure to light. Soluble 1 in 45 of water, 1 in 50 of alcohol, and 1 in 5 of 3N hydrochloric acid; very slightly soluble in carbon tetrachloride, in chloroform, in ether, and in benzene; freely soluble in alkaline solutions with some decomposition, and in diluted hydrochloric acid. Store in airtight containers. Protect from light.
💊 Adverse Effects
Sodium aminohippurate may cause nausea and vomiting, hypersensitivity reactions, vasomotor disturbances, flushing, tingling, cramps, and a feeling of warmth. Patients may develop an urge to urinate or defaecate after infusion.
The estimation of sodium aminohippurate may be affected in patients taking procaine, sulfonamides, or thiazosulfone. Probenecid diminishes the excretion of aminohippuric acid. Clearance is also affected by penicillins, salicylates, and other drugs that compete for the same excretory pathways.
💊 Uses and Administration
Aminohippuric acid is excreted mainly by proximal tubular secretion, with some glomerular filtration. It is given by intravenous infusion, as sodium aminohippurate (aminohippurate sodium; C9H9N2NaO3= 216.2), for the estimation of effective renal plasma flow. Doses are aimed at producing a plasma concentration of 20 micrograms/mL; at these concentrations about 90% of aminohippurate is cleared from the renal bloodstream in a single circuit in patients with normal renal function. Sodium aminohippurate has also been used for the assessment of the renal tubular secretory mechanism. Doses for this purpose are infused slowly to achieve a plasma concentration of 400 to 600 micrograms/mL to saturate the tubular secretion. These tests are used mainly in research procedures.
USP 31: Aminohippurate Sodium Injection.
Published December 10, 2018.