Alum

(rINN)

💊 Chemical information

Alaun; Allume; Aluin; Alumbre; Alumen; Aluminium Kalium Sulfuricum; Aluminium Potassium Sulphate; Alumínium-káliumszulfát; Alun; Aluna; Alu _ nas; E522; Glinowopotasowy siarczan; Glinu potasu siarczan; Kalii Aluminii Sulfas Dodecahydricus; Potash Alum; Potassium Alum; Síran draselno-hlinitý dodekahydrát.
Potassium aluminium sulphate dodecahydrate.
Chemical formula: AlK(SO4)2,12H2O = 474.4.
CAS — 7784-24-9 (alum dodecahydrate); 10043-67-1 ATC — S01XA07.
ATC Vet — QS01XA07.

Pharmacopoeias.

In Chin., Eur., Jpn, and US. US also includes dodecahydrated ammonia alum (Ammonium Alum). Jpn also includes dried alum.

Ph. Eur. 6.2

(Alum). Colourless, transparent, crystalline masses or a granular powder. Freely soluble in water; very soluble in boiling water; practically insoluble in alcohol; soluble in glycerol. A 10% solution in water has a pH of 3.0 to 3.5.

USP 31

(Potassium Alum). A white powder or large, colourless crystals or crystalline fragments. It is odourless. Soluble 1 in 7 of water and 1 in 0.3 of boiling water; insoluble in alcohol; freely but slowly soluble in glycerol. Its solutions are acid to litmus. Store in airtight containers.

💊 Adverse Effects

Large doses of alum are irritant and may be corrosive; gum necrosis and gastrointestinal haemorrhage have occurred. Systemic absorption from bladder irrigation solutions can cause acute aluminium toxicity (see under Aluminium below) including encephalopathy. Anecdotal evidence would suggest that this practice should be avoided in patients with renal insufficiency.1
1. Phelps KR, et al. Encephalopathy after bladder irrigation with alum: case report and literature review. Am J Med Sci 1999; 318: 181–5
2. Nakamura H, et al. Acute encephalopathy due to aluminium toxicity successfully treated by combined intravenous deferoxamine and hemodialysis. J Clin Pharmacol 2000; 40: 296–300.

💊 Uses and Administration

Alum precipitates proteins and is a powerful astringent. It is often included in preparations used as mouthwashes or gargles and in dermatological preparations. Alum, either as a solid or as a solution, may be used as a haemostatic. Intravesical instillation of alum, typically as a 1% solution, has been used as a treatment for haemorrhagic cystitis. Alum is also used as a mordant in the dyeing industry.

💊 Preparations

Proprietary Preparations

Ger.: Citramin†. Multi-ingredient: Arg.: Bentophyto; Austria: EST; Braz.: Lucretin; Canad.: Fletchers Sore Mouth Medicine; Ger.: Retterspitz Ausserlich; Retterspitz Innerlich; India: Feel Chill; Ital.: Lavanda Sofar; Mex.: Forcremol; Neth.: Trachitol; NZ: Grans Remedy; Spain: Co Bucal; Lindemil; USA: BFI; Massengill; Mycinette; Venez.: Borogin.
Published December 02, 2018.