Allyl Isothiocyanate

(USAN)

💊 Chemical information

Isothiocyanato-l-propene.
Chemical formula: C4H5NS = 99.15.
CAS — 57-06-7.

Pharmacopoeias.

Fr. and US

USP 31

(Allyl Isothiocyanate). A colourless to pale yellow, very refractive, liquid with a pungent, irritating odour and an acrid taste. Slightly soluble in water; miscible with alcohol, with carbon disulfide, and with ether. Store in airtight containers.

💊 Profile

Black and white mustard seeds have been used as emetics, in counter-irritant and rubefacient preparations, and as condiments. Volatile mustard oil, prepared from black mustard seeds, is largely composed of allyl isothiocyanate. It is an extremely powerful irritant that has been used as a counter-irritant and rubefacient. Expressed mustard oil contains a smaller proportion of volatile oil and has been used as a less powerful counter-irritant.

Adverse effects.

A report of 2 cases of IgE-mediated anaphylaxis to mustard condiment.1
1. Vidal C, et al. Anaphylaxis to mustard. Postgrad Med J 1991; 67: 404.

Handling.

Allyl isothiocyanate is a potent lachrymator, with a pungent irritating odour. Care should be taken to protect the eyes, to prevent inhalation of fumes, and to avoid tasting.

💊 Preparations

Proprietary Preparations

Mon.: Autoplasme Vaillant; Sinapisme Rigollot. Multi-ingredient: Braz.: Aliviol; Analgen†; Benegel; Gelflex; Gelol†; Gelonevral†; Mialgex†; Mostardina†; Nevrol; Canad.: Rheumalan†; Cz.: Apisarthron; Rheumosin†; Ger.: Cor-Select†; Pol.: Reumobonisol; Rus.: Apisarthron (Апизартрон); Efcamon (Эфкамон); Spain: Dolokey; Switz.: Knobel Huile N; UK: Nine Rubbing Oils; Radian-B Red Oils; Red Oil; USA: Dermolin; Methalgen†; Musterole Extra.
Published May 08, 2019.