Aflatoxins

(rINN)

Chemical information

Aflatoxinas.
CAS — 1162-65-8 (aflatoxin B 1 ); 7220-81-7 (aflatoxin B 2 ); 1165-39-5 (aflatoxin G 1 ); 7241-98-7 (aflatoxin G 2 ); 6795-23-9 (aflatoxin M 1 ); 6885-57-0 (aflatoxin M 2 ).

Profile

Aflatoxins are toxic metabolites produced by many strains of Aspergillus flavus and A. parasiticus, growing on many vegetable foods, notably maize and peanuts. A number of forms, including aflatoxins B1, B2, G1, and G2 have been identified. Aflatoxins M1and M2 are metabolites produced by animals after ingestion of aflatoxins B1 and B2; they may be detected in cows’ milk. Aflatoxins can cause hepatitis and cirrhosis. They have been implicated in liver cancer, and may act as co-carcinogens with hepatitis B virus. Aflatoxin B1 is reported to be one of the most potent carcinogens known in animals. It has been reported that aflatoxins have been developed in some countries as biological weapons.
1. Ross RK, et al. Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma. Lancet 1992; 339: 943–6
2. Jackson PE, Groopman JD. Aflatoxin and liver cancer. Baillieres Best Pract Res Clin Gastroenterol 1999; 13: 545–55
3. Peraica M, et al. Toxic effects of mycotoxins in humans. Bull WHO 1999; 77: 754–66
4. Pitt JI. Toxigenic fungi and mycotoxins. Br Med Bull 2000; 56: 184–92.
Published November 17, 2018.