Synonyms: Afélimomab; Afelimomabum; MAK-195F. Immunoglobulin G3, anti-(human tumor necrosis factor monoclonal LU54107 clonal LU54107
Cyrillic synonym: Афелимомаб.

Chemical information

CAS — 156227-98-4.
ATC — L04AB03.
ATC Vet — QL04AB03.


Afelimomab is a monoclonal tumour necrosis factor antibody that has been investigated for the treatment of sepsis.
1. Vincent JL. Afelimomab. Int J Clin Pract 2000; 54: 190–3
2. Reinhart K, et al. Randomized, placebo-controlled trial of the anti-tumor necrosis factor antibody fragment afelimomab in hyperinflammatory response during severe sepsis: the RAMSES study. Crit Care Med 2001; 29: 765–9
3. Gallagher J, et al. A multicenter, open-label, prospective, randomized, dose-ranging pharmacokinetic study of the anti-TNFalpha antibody afelimomab in patients with sepsis syndrome. Intensive Care Med. 2001; 27: 1169–78
4. Panacek EA, et al. Efficacy and safety of the monoclonal antitumor necrosis factor antibody F(ab’)2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels. Crit Care Med 2004; 32: 2173–82.
Published November 16, 2018.