Benzyl Benzoate

(BAN)
Benzyl Benzoate Chemical formula

💊 Chemical information

Bencilo, benzoato de; Bensylbensoat; Bentsyylibentsoaatti; Benzil Benzoat; Benzil-benzoát; Benzilbenzoatas; Benzoato de bencilo; Benzoato de Benzilo; Benzoesäurebenzylester; Benzyl Benz.; Benzyl-benzoát; Benzyle, benzoate de; Benzylis benzoas; Benzylu benzoesan.
Chemical formula: C6H5.CO.O.CH2.C6H5 = 212.2.
CAS — 120-51-4.
ATC — P03AX01.
ATC Vet — QP5 3AX11.

Pharmacopoeias.

In Eur., Int., Jpn, and US.

Ph. Eur. 6.2

(Benzyl Benzoate). Colourless or almost colourless crystals, or a colourless or almost colourless oily liquid. F.p. is not below 17°. Practically insoluble in water; miscible with alcohol, with dichloromethane, and with fatty and essential oils. Store in well-filled airtight containers. Protect from light.

USP 31

(Benzyl Benzoate). A clear, colourless, oily liquid with a slight aromatic odour. Practically insoluble in water and in glycerol; miscible with alcohol, with chloroform, and with ether. Store at a temperature not exceeding 40° in well-filled airtight containers. Protect from light.

💊 Adverse Effects and Treatment

Benzyl benzoate is irritant to the eyes and mucous membranes and it may be irritant to the skin. Hypersensitivity reactions have been reported. If ingested, benzyl benzoate may cause stimulation of the CNS and convulsions. Systemic symptoms have been reported on excessive topical use. For poisoning associated with topical use the skin should be washed. Appropriate symptomatic measures should also be instituted.

💊 Uses and Administration

Benzyl benzoate is an acaricide used in the treatment of scabies although other treatments are generally preferred. A 25% emulsion is applied to the whole body, usually from the neck down (although the BNF considers that application should be extended to the scalp, neck, face, and ears). If the application is thorough, one treatment may suffice, although the possibility of failure is lessened by a second application within 5 days. Alternatively, three applications at 12-hour intervals, without bathing, may be made, followed by bathing 12 hours after the last application. The BNF recommends one application to the whole body, repeated, without bathing, on the next day, and washed off 24 hours later; a third application may sometimes be necessary. Benzyl benzoate is not generally recommended for infants and children, but if used the application should be diluted to minimise the risk of irritation, although this also reduces efficacy. Benzyl benzoate has also been used as a pediculicide. Benzyl benzoate is also used as a solubilising agent.

💊 Preparations

BP 2008: Benzyl Benzoate Application; USP 31: Benzyl Benzoate Lotion.

Proprietary Preparations

Austral.: Ascabiol; Benzemul; Braz.: Acarsan; Bencocan; Benzibel†; Benzin†; Benzoax; Benzoben†; Benzocan†; Benzolato†; Benzolina†; Benzolom†; Benzotisan; Miticocan; Parasimed; Pruridol; Sanasar; Sarnaton†; Sarnezan†; Sarnilab; Sarnodex; Scabenzil; Scabioid; Zilaben; Ger.: Acaril†; Acarosan†; Antiscabiosum; Gr.: Benzogal; Irl.: Ascabiol†; Israel: Scabiex; Ital.: Mom Lozione Preventiva; Mex.: Ansar; Hastilan; Pol.: Novoscabin; Port.: Acarilbial; Neo-Acarina†; Piozil; S.Afr.: Ascabiol; UK: Ascabiol; Venez.: Benzalcor; Benzo-Bencil; Benzodit†; Niostal†. Multi-ingredient: Arg.: Anusol Duo S; Anusol-A; Arnecrem†; Bencil Scab; Detebencil; Hexabencil; Perbel; Permecil; Sapucai†; Scabioderm; Austral.: Anusol; Belg.: Pulmex; Pulmex Baby; Braz.: Anusol-HC; Fr.: Allerbiocid S†; Ascabiol; Sanytol†; Hong Kong: Anusol-HC†; Hung.: Novascabin; Irl.: Anugesic-HC; Anusol-HC; Ital.: Antiscabbia Candioli al DDT Terapeutico; Antiscabbia CM; Dekar 2; Prurex; Skab 2; Malaysia: Anucare; Anusol; NZ: Anusol; Pol.: Cetriscabin; S.Afr.: Anugesic; Singapore: Anusol; Spain: Tulgrasum Cicatrizante; Yacutin; Swed.: Tenutex; Thai.: Anusol; UK: Anugesic-HC; Anusol-HC, Plus HC; Sudocrem; USA: Anumed; Anumed HC; Hemril; Venez.: Kertyol.
Published October 18, 2018.